التفاصيل البيبلوغرافية
| العنوان: |
Corpus callosum atrophy and post-surgical seizures in temporal lobe epilepsy associated with hippocampal sclerosis. |
| المؤلفون: |
Uribe-San-Martín, Reinaldo1,2 ruribe@med.puc.cl, Ciampi, Ethel1,2, Di Giacomo, Roberta3, Vásquez, Macarena1, Cárcamo, Claudia1, Godoy, Jaime1, Lo Russo, Giorgio4, Tassi, Laura4 |
| المصدر: |
Epilepsy Research. May2018, Vol. 142, p29-35. 7p. |
| مصطلحات موضوعية: |
*DRUG therapy for convulsions, *EPILEPSY risk factors, *BIOLOGICAL tags, *ATROPHY, *OPERATIVE surgery, *DISEASE risk factors |
| مستخلص: |
Objective Our aim in this retrospective study was to explore whether corpus callosum atrophy could predict the post-surgical seizure control in patients with temporal lobe epilepsy associated with Hippocampal Sclerosis (HS). Methods We used the Corpus Callosum Index (CCI) obtained from best mid-sagittal T2/FLAIR or T1-weighted MRI at two time-points, more than one year apart. CCI has been mainly used in Multiple Sclerosis (MS), but not in epilepsy, so we tested the validity of our results performing a proof of concept cohort, incorporating MS patients with and without epilepsy. Then, we explored this measurement in a well-characterized and long-term cohort of patients with temporal lobe epilepsy associated with HS. Results In the proof of concept cohort (MS without epilepsy n:40, and MS with epilepsy, n:15), we found a larger CCI atrophy rate in MS patients with poor epilepsy control vs. MS without epilepsy (p:0.01). Then, in HS patients (n:74), annualized CCI atrophy rate was correlated with the long-term Engel scale (Rho:0.31, p:0.007). In patients with post-surgical seizure recurrence, a larger CCI atrophy rate was found one year before any seizure relapse. Univariate analysis showed an increased risk of seizure recurrence in males, higher pre-surgical seizure frequency, necessity of invasive EEG monitoring, and higher CCI atrophy rate. Two of these variables were independent predictors in the multivariate analysis, male gender (HR:4.87, p:0.002) and CCI atrophy rate (HR:1.21, p:0.001). Conclusion We demonstrated that atrophy of the corpus callosum, using the CCI, is related with poor seizure control in two different neurological disorders presenting with epilepsy, which might suggest that corpus callosum atrophy obtained in early post-surgical follow-up, could be a biomarker for predicting recurrences and guiding treatment plans. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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