Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection
العنوان: | Intracarotid amobarbital disrupts synchronous and nested oscillatory activity ipsilateral to injection |
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المؤلفون: | James J. Young, Johanna T Fifi, Christina A Palmese, Saadi Ghatan, Lara V. Marcuse, Thomas J Oxley, Fedor Panov, Joshua Friedman |
المصدر: | Epilepsy and Behavior Case Reports, Vol 10, Iss, Pp 25-28 (2018) Epilepsy & Behavior Case Reports |
بيانات النشر: | Elsevier, 2018. |
سنة النشر: | 2018 |
مصطلحات موضوعية: | 0301 basic medicine, Amobarbital, Wada, Article, Stereo-EEG, lcsh:RC321-571, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Phase amplitude coupling, Epilepsy surgery, Stereo eeg, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Gamma power, business.industry, Synchrony, 030104 developmental biology, Neurology, Anesthesia, Intracarotid amobarbital procedure, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug |
الوصف: | The mechanism of amobarbital action during the intracarotid amobarbital procedure is poorly understood. We report a patient case who underwent IAP while implanted with bilateral stereo-EEG. We analyzed the spectral power, phase amplitude coupling, and cluster-phase group synchrony during the procedure. Delta and gamma power increased bilaterally. By contrast, phase amplitude coupling increased only ipsilateral to the injection. Similarly, 4–30 Hz cluster-phase group synchrony declines and gamma cluster-phase group synchrony increases only ipsilateral to the injection. These results suggest that a possible additional mechanism for amobarbital action in the IAP is by altering the precise timing of oscillatory activity. Highlights • Intracranial activity shows bilateral increases in delta and gamma activity during the IAP. • Phase amplitude coupling increases in the 2–3 Hz (phase) and 30–70 Hz (amplitude) band only ipsilateral to the injection. • 4–30 Hz synchrony declines and gamma synchrony increases only ipsilateral to the injection. • Amobarbital may alter the temporal organization of activity, rather than inactivation of the injected hemisphere. |
اللغة: | English |
تدمد: | 2213-3232 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6994f88c1f1e6353c3cbcd17b390219cTest http://www.sciencedirect.com/science/article/pii/S2213323218300148Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....6994f88c1f1e6353c3cbcd17b390219c |
قاعدة البيانات: | OpenAIRE |
تدمد: | 22133232 |
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