التفاصيل البيبلوغرافية
| العنوان: |
RKIP expression of liver and kidney after arsenic exposure |
| المؤلفون: |
Huoy-Rou Chang, Wei-Chang Tseng, Der-An Tsao |
| المصدر: |
Environmental Toxicology. 32:1079-1082 |
| بيانات النشر: |
Wiley, 2016. |
| سنة النشر: |
2016 |
| مصطلحات موضوعية: |
0301 basic medicine, medicine.medical_specialty, Health, Toxicology and Mutagenesis, chemistry.chemical_element, Management, Monitoring, Policy and Law, Biology, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Gene expression, medicine, ARSENIC EXPOSURE, Arsenic, Kidney, Liver and kidney, Cancer, General Medicine, medicine.disease, Blot, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Immunology, Immunohistochemistry |
| الوصف: |
Arsenic is associated with cancers of kidney and liver. Raf kinase inhibitor protein (RKIP) has been identified as a member of a novel class of molecules that suppress the metastatic spread of tumors. In order to investigate the effect of arsenic to RKIP of liver and kidney, the expression of RKIP of liver and kidney with As (III) was explored in this study. Thirty male mice were chronically fed with 42.5 ppm, 85 ppm NaAsO2 and water for 180 days. The kidney and liver accumulation levels of As (III) in mice were determined by electro-thermal atomic absorption spectrometry. The method of RT-PCR, Western blotting analysis and immunohistochemistry were used to determine gene expression and protein expression of RKIP. The results showed that arsenic level was significantly increased in kidney and liver of As (III)-exposed mice as compared with control group. The gene expression and protein expression of RKIP was significantly decreased in kidney and liver of As (III)-exposed mice in comparison with these of control mice. These data suggested that RKIP decrease of liver and kidney with As (III) may be dangerous index in formation of cancer. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1079-1082, 2017. |
| تدمد: |
1520-4081 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_________::369dd3ee1da31ccc7744e58ba2880389Test
https://doi.org/10.1002/tox.22291Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi...........369dd3ee1da31ccc7744e58ba2880389 |
| قاعدة البيانات: |
OpenAIRE |
