Neuroendocrine disruption by bisphenol A and/or di(2-ethylhexyl) phthalate after prenatal, early postnatal and lactational exposure
| العنوان: | Neuroendocrine disruption by bisphenol A and/or di(2-ethylhexyl) phthalate after prenatal, early postnatal and lactational exposure |
|---|---|
| المؤلفون: | Pinar Erkekoglu, Belma Kocer-Gumusel, Naciye Dilara Zeybek, Nilgün Yersal, Aylin Balci, Anıl Yirün, Gizem Özkemahlı |
| المساهمون: | EBYÜ, Eczacılık Fakültesi |
| المصدر: | Environmental Science and Pollution Research. 28:26961-26974 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system, Offspring, Health, Toxicology and Mutagenesis, Physiology, 010501 environmental sciences, medicine.disease_cause, 01 natural sciences, Lipid peroxidation, chemistry.chemical_compound, Lactation, medicine, Environmental Chemistry, Endocrine system, 0105 earth and related environmental sciences, business.industry, Neurotoxicity, Phthalate, General Medicine, medicine.disease, Pollution, medicine.anatomical_structure, chemistry, Toxicity, business, Apoptosis . Bisphenol A . Di(2-ethylhexyl) phthalate . Endocrine disrupting chemicals . Lactational exposure . Neurotoxicity . Oxidative stress . Prenatal exposure, Oxidative stress |
| الوصف: | Bisphenol A (BPA) and di(2-ethylhexyl)phthalate (DEHP) are abundant endocrine disrupting chemicals (EDCs). In recent years, studies showed that EDCs may lead to neurodevelopmental diseases. The effects of prenatal exposure to these chemicals may have serious consequences. Moreover, exposure to EDCs as a mixture may have different effects than individual exposures. The present study aimed to determine the toxicity of BPA and/or DEHP on central nervous system (CNS) and neuroendocrine system in prenatal and lactational period in Sprague-Dawley rats. Pregnant rats were randomly divided into four groups: control (received vehicle); BPA group (received BPA at 50 mg/kg/day); DEHP group (received DEHP at 30 mg/kg/day); and combined exposure group (received both BPA at 50 mg/kg/day and DEHP at 30 mg/kg/day) during pregnancy and lactation by oral gavage. At the end of lactation, male offspring (n = 6) were randomly grouped. The alterations in the brain histopathology, neurotransmitter levels and enzyme activities in the cerebrum region, oxidative stress markers, and apoptotic effects in the hippocampus region were determined at adulthood. The results showed that exposure to EDCs at early stages of life caused significant changes in lipid peroxidation, total GSH and neurotransmitter levels, and activities of neurotransmitter-related enzymes. Moreover, BPA and/or DEHP led to apoptosis and histopathologic alterations in the hippocampus. Therefore, we can suggest that changes in oxidant/antioxidant status, as well as in neurotransmitters and related enzymes, can be considered as the underlying neurotoxicity mechanisms of BPA and DEHP. However, more mechanistic studies are needed. |
| وصف الملف: | application/pdf |
| تدمد: | 1614-7499 0944-1344 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c4f39f85b63568713d06114c3020cTest https://doi.org/10.1007/s11356-021-12408-9Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3a7c4f39f85b63568713d06114c3020c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16147499 09441344 |
|---|