التفاصيل البيبلوغرافية
| العنوان: |
Antibacterial application of covalently immobilized photosensitizers on a surface. |
| المؤلفون: |
Kim, Han-Shin1 (AUTHOR), Cha, Eun Ji1 (AUTHOR), Kang, Hyun-Jin1 (AUTHOR), Park, Jeong-Hoon1 (AUTHOR), Lee, Jaesang1 (AUTHOR), Park, Hee-Deung1,2 (AUTHOR) heedeung@korea.ac.kr |
| المصدر: |
Environmental Research. May2019, Vol. 172, p34-42. 9p. |
| مصطلحات موضوعية: |
*REACTIVE oxygen species, *SILANE coupling agents, *FOURIER transform infrared spectroscopy, *HYDROXYL group, *PHOTOSENSITIZERS, *GRAM-positive bacteria |
| مستخلص: |
Singlet oxygen produced by irradiating photosensitizers (PSs) can be used to kill pathogens during water treatment. Chemical immobilization of the PSs on surfaces can maintain their disinfection function long-term. In this study, two model PSs (rose bengal (RB) and hematoporphyrin (HP)) were immobilized on a glass surface using a silane coupling agent with an epoxide group, and their antibacterial properties were analyzed. Fourier transform infrared spectroscopy demonstrated that a covalent bond formed between the epoxide group and hydroxyl group in the PSs. A large proportion of the immobilized PSs (approximately 50%) was active in singlet oxygen production, which was evidenced by a comparative analysis with free PSs. RB was more effective at producing singlet oxygen than HP. The immobilized PSs were durable in terms of repeated use. On the other hand, singlet oxygen produced by the PSs was effective at killing bacteria, mostly for Gram-positive bacteria (> 90% death for 2 h of irradiation), by damaging the cell membrane. The preferable antibacterial property against Gram-positive bacteria compared with that against Gram-negative bacteria suggested efficient penetrability of singlet oxygen across the cell membrane, which led to cell death. Taken together, it was concluded that immobilization of PSs on surfaces using the silane coupling agent proposed in this study was effective at killing Gram-positive bacteria by forming singlet oxygen. • A silane coupler with epoxide was efficient in covalently binding PSs on a surface. • Irradiation of the PS-immobilized surface produced large amount of singlet oxygen. • Gram-positive bacteria were effectively killed by the produced singlet oxygen. • Significant antibacterial property was maintained for repeated use of the surface. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
