التفاصيل البيبلوغرافية
| العنوان: |
Occupational Lead Exposure and Associations with Selected Cancers: The Shanghai Men's and Women's Health Study Cohorts. |
| المؤلفون: |
Liao, Linda M., Friesen, Melissa C., Xiang, Yong-Bing, Cai, Hui, Koh, Dong-Hee, Ji, Bu-Tian, Yang, Gong, Li, Hong-Lan, Locke, Sarah J., Rothman, Nathaniel, Zheng, Wei, Gao, Yu-Tang, Shu, Xiao-Ou, Purdue, Mark P. |
| المصدر: |
Environmental Health Perspectives; Jan2016, Vol. 124 Issue 1, p97-103, 7p, 4 Charts |
| مصطلحات موضوعية: |
BRAIN tumor risk factors, BRAIN tumors, CONFIDENCE intervals, EPIDEMIOLOGICAL research, KIDNEY tumors, LEAD, LONGITUDINAL method, LUNG tumors, MENINGIOMA, RESEARCH funding, OCCUPATIONAL hazards, STOMACH tumors, ENVIRONMENTAL exposure, DISEASE incidence, PROPORTIONAL hazards models, DESCRIPTIVE statistics, TUMOR risk factors, DISEASE risk factors |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
BACKGROUND: Epidemiologic studies of occupational lead exposure have suggested increased risks of cancers of the stomach, lung, kidney, brain, and meninges; however, the totality of the evidence is inconsistent. OBJECTIVE: We investigated the relationship between occupational lead exposure and cancer incidence at the five abovementioned sites in two prospective cohorts in Shanghai, China. METHODS: Annual job/industry-specific estimates of lead fume and lead dust exposure, derived from a statistical model combining expert lead intensity ratings with inspection measurements, were applied to the lifetime work histories of participants from the Shanghai Women's Health Study (SWHS; n = 73,363) and the Shanghai Men's Health Study (SMHS; n = 61,379) to estimate cumulative exposure to lead fume and lead dust. These metrics were then combined into an overall occupational lead exposure variable. Cohort-specific relative hazard rate ratios (RRs) and 95% confidence intervals (CIs) comparing exposed and unexposed participants were estimated using Cox proportional hazards regression and combined by meta-analysis. RESULTS: The proportions of SWHS and SMHS participants with estimated occupational lead exposure were 8.9% and 6.9%, respectively. Lead exposure was positively associated with menin-gioma risk in women only (n = 38 unexposed and 9 exposed cases; RR = 2.4; 95% CI: 1.1, 5.0), particularly with above-median cumulative exposure (RR = 3.1; 95% CI: 1.3, 7.4). However, all 12 meningioma cases among men were classified as unexposed to lead. We also observed nonsignificant associations with lead exposure for cancers of the kidney (n = 157 unexposed and 17 ever exposed cases; RR = 1.4; 95% CI: 0.9, 2.3) and brain (n = 67 unexposed and 10 ever exposed cases; RR = 1.8; 95% CI: 0.7, 4.8) overall. CONCLUSIONS: Our findings, though limited by small numbers of cases, suggest that lead is associated with the risk of several cancers in women and men. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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