Circadian effects of ionizing radiation on reproductive function and clock genes expression in male mouse
| العنوان: | Circadian effects of ionizing radiation on reproductive function and clock genes expression in male mouse |
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| المؤلفون: | Yingjie Xu, Tao Shen, Hailong Pei, Ning-Ang Liu, Guangming Zhou, Shuxian Pan, Jing Nie, Fenju Qin |
| المصدر: | Environmental Health and Preventive Medicine |
| بيانات النشر: | BioMed Central, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Ionizing radiation, Male, L-Iditol 2-Dehydrogenase, Sorbitol dehydrogenase, Acid Phosphatase, CLOCK Proteins, Gene Expression, Biology, Genitalia, Male, Glucosephosphate Dehydrogenase, Reproductive marker, Andrology, Mice, Radiation, Ionizing, Testis, medicine, Animals, Circadian rhythm, RNA, Messenger, Clock genes, Sperm motility, Testosterone, Epididymis, Reproductive function, L-Lactate Dehydrogenase, Reproductive Physiological Phenomena, Public Health, Environmental and Occupational Health, ARNTL Transcription Factors, Nuclear Receptor Subfamily 1, Group F, Member 2, Nuclear Receptor Subfamily 1, Group F, Member 1, General Medicine, Nuclear Receptor Subfamily 1, Group F, Member 3, Radiation Exposure, Spermatozoa, CLOCK, Mice, Inbred C57BL, medicine.anatomical_structure, Models, Animal, Sperm Motility, Spermatogenesis, Research Article |
| الوصف: | Background Exposure to the ionizing radiation (IR) encountered outside the magnetic field of the Earth poses a persistent threat to the reproductive functions of astronauts. The potential effects of space IR on the circadian rhythms of male reproductive functions have not been well characterized so far. Methods Here, we investigated the circadian effects of IR exposure (3 Gy X-rays) on reproductive functional markers in mouse testicular tissue and epididymis at regular intervals over a 24-h day. For each animal, epididymis was tested for sperm motility, and the testis tissue was used for daily sperm production (DSP), testosterone levels, and activities of testicular enzymes (glucose-6-phosphate dehydrogenase (G6PDH), sorbitol dehydrogenase (SDH), lactic dehydrogenase (LDH), and acid phosphatase (ACP)), and the clock genes mRNA expression such as Clock, Bmal1, Ror-α, Ror-β, or Ror-γ. Results Mice exposed to IR exhibited a disruption in circadian rhythms of reproductive markers, as indicated by decreased sperm motility, increased daily sperm production (DSP), and reduced activities of testis enzymes such as G6PDH, SDH, LDH, and ACP. Moreover, IR exposure also decreased mRNA expression of five clock genes (Clock, Bmal1, Ror-α, Ror-β, or Ror-γ) in testis, with alteration in the rhythm parameters. Conclusion These findings suggested potential health effects of IR exposure on reproductive functions of male astronauts, in terms of both the daily overall level as well as the circadian rhythmicity. |
| اللغة: | English |
| تدمد: | 1347-4715 1342-078X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260bf50ca430622e16381dd1aae51496Test http://europepmc.org/articles/PMC8507176Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....260bf50ca430622e16381dd1aae51496 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474715 1342078X |
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