Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China
| العنوان: | Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China |
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| المؤلفون: | Yan An, Jian Liu, Huanyu Jin, Kenzo Yamanaka, Sanxiang Wang, Dapeng Wang, Yasuyo Shimoda, Fenfang Gao, Xing Liu, Zhenghui Wang, Jian Tong, Jie Zhang |
| المصدر: | Environmental Health and Preventive Medicine Environmental Health and Preventive Medicine, Vol 22, Iss 1, Pp 1-9 (2017) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, inorganic chemicals, Adult, Male, Saliva, China, media_common.quotation_subject, chemistry.chemical_element, Urine, 010501 environmental sciences, Positive correlation, 01 natural sciences, Arsenicals, Arsenic, Toxicology, 03 medical and health sciences, Young Adult, Humans, ARSENIC EXPOSURE, Chromatography, High Pressure Liquid, 0105 earth and related environmental sciences, media_common, Aged, integumentary system, lcsh:Public aspects of medicine, Drinking Water, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, General Medicine, Biomarker, Middle Aged, Speciation, 030104 developmental biology, chemistry, Environmental chemistry, Arsenic speciation, Positive relationship, Female, Skin lesion, Biomarkers, Water Pollutants, Chemical, Environmental Monitoring, Research Article |
| الوصف: | Background It is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivary arsenic as a new biomarker of arsenic exposure. Methods Total arsenic and speciation analyses in urine and saliva samples among 70 residents exposed to arsenic from drinking water in Shanxi, China were carried out by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP/MS). Results The result showed that, total arsenic concentration in saliva was relatively lower than in urine samples, but it existed a strong positive correlation with total urinary arsenic, drinking water arsenic and different skin lesions. For arsenic metabolism analyses, AsIII, AsV, MMA, and DMA were detected in all of the urine samples with the dominating species of DMA (73.2%). Different with urinary arsenic species, most arsenic species in saliva were not methylated. The major species in saliva was iAs (AsIII + AsV, 76.18%), followed by DMA (13.08%) and MMA (9.13%). And the primary methylation index (PMI), second methylation index (SMI) and proportion of the four different species (AsIII, AsV, MMA, and DMA) in saliva showed no significant positive relationship with that of in urine. Conclusions These findings indicated saliva may be used as a useful tool for biological monitoring of total arsenic exposure in the crowd rather than an efficient tool for assessing arsenic metabolism in human body after exposed to arsenic. |
| تدمد: | 1347-4715 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e5f8a3c4b00975ae31f087930475e0Test https://pubmed.ncbi.nlm.nih.gov/29165156Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....79e5f8a3c4b00975ae31f087930475e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474715 |
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