The Role of Incretins on Insulin Function and Glucose Homeostasis
| العنوان: | The Role of Incretins on Insulin Function and Glucose Homeostasis |
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| المؤلفون: | Lærke S. Gasbjerg, Jens J. Holst, Mette M. Rosenkilde |
| المصدر: | Endocrinology Holst, J J, Gasbjerg, L S & Rosenkilde, M M 2021, ' The role of incretins on insulin function and glucose homeostasis ', Endocrinology, vol. 162, no. 7, bqab065 . https://doi.org/10.1210/endocr/bqab065Test |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, medicine.medical_specialty, endocrine system, glucagon-like peptide-1 (GLP-1), hormone coagonists, medicine.medical_treatment, Incretin, Type 2 diabetes, Gastric Inhibitory Polypeptide, Incretins, Receptors, Gastrointestinal Hormone, Endocrinology, Glucagon-Like Peptide 1, Internal medicine, Insulin Secretion, medicine, Glucose homeostasis, Homeostasis, Humans, Insulin, Secretion, Mini-Reviews, exendin 9-39, business.industry, digestive, oral, and skin physiology, medicine.disease, Postprandial Period, Postprandial, Diabetes Mellitus, Type 2, hormone antagonists, glucose-dependent insulinotropic polypeptide (GIP), business, Function (biology), hormones, hormone substitutes, and hormone antagonists, AcademicSubjects/MED00250, Hormone |
| الوصف: | The incretin effect—the amplification of insulin secretion after oral vs intravenous administration of glucose as a mean to improve glucose tolerance—was suspected even before insulin was discovered, and today we know that the effect is due to the secretion of 2 insulinotropic peptides, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). But how important is it? Physiological experiments have shown that, because of the incretin effect, we can ingest increasing amounts of amounts of glucose (carbohydrates) without increasing postprandial glucose excursions, which otherwise might have severe consequences. The mechanism behind this is incretin-stimulated insulin secretion. The availability of antagonists for GLP-1 and most recently also for GIP has made it possible to directly estimate the individual contributions to postprandial insulin secretion of a) glucose itself: 26%; b) GIP: 45%; and c) GLP-1: 29%. Thus, in healthy individuals, GIP is the champion. When the action of both incretins is prevented, glucose tolerance is pathologically impaired. Thus, after 100 years of research, we now know that insulinotropic hormones from the gut are indispensable for normal glucose tolerance. The loss of the incretin effect in type 2 diabetes, therefore, contributes greatly to the impaired postprandial glucose control. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1945-7170 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f9548199a7e72695956c9f5082352fTest http://europepmc.org/articles/PMC8168943Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d5f9548199a7e72695956c9f5082352f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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