The Angiostatic Protein 16K Human Prolactin Significantly Prevents Tumor-Induced Lymphangiogenesis by Affecting Lymphatic Endothelial Cells
| العنوان: | The Angiostatic Protein 16K Human Prolactin Significantly Prevents Tumor-Induced Lymphangiogenesis by Affecting Lymphatic Endothelial Cells |
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| المؤلفون: | Agnès Noël, Virginie Kinet, Michelle Lion, Karolien Castermans, Stéphanie Herkenne, Ingrid Struman, Silvia Blacher, Joseph Martial, Catherine Maillard |
| المصدر: | Endocrinology; Vol 152 |
| بيانات النشر: | The Endocrine Society, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Angiogenesis, government.form_of_government, Apoptosis, Biology, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Angiostatic Proteins, medicine, Animals, Humans, Lymphangiogenesis, Cells, Cultured, Cell Proliferation, Lymphatic Vessels, 030304 developmental biology, Tube formation, 0303 health sciences, Neovascularization, Pathologic, Endothelial Cells, medicine.disease, Primary tumor, Peptide Fragments, Prolactin, 3. Good health, Lymphatic Endothelium, Lymphatic system, 030220 oncology & carcinogenesis, government, Female, Lymph Nodes, Lymph |
| الوصف: | The 16-kDa angiostatic N-terminal fragment of human prolactin (16K hPRL) has been reported to be a new potent anticancer compound. This protein has already proven its efficiency in several mouse tumor models in which it prevented tumor-induced angiogenesis and delayed tumor growth. In addition to angiogenesis, tumors also stimulate the formation of lymphatic vessels, which contribute to tumor cell dissemination and metastasis. However, the role of 16K hPRL in tumor-induced lymphangiogenesis has never been investigated. We establish in vitro that 16K hPRL induces apoptosis and inhibits proliferation, migration, and tube formation of human dermal lymphatic microvascular endothelial cells. In addition, in a B16F10 melanoma mouse model, we found a decreased number of lymphatic vessels in the primary tumor and in the sentinel lymph nodes after 16K hPRL treatment. This decrease is accompanied by a significant diminished expression of lymphangiogenic markers in primary tumors and sentinel lymph nodes as determined by quantitative RT-PCR. These results suggest, for the first time, that 16K hPRL is a lymphangiostatic as well as an angiostatic agent with antitumor properties. |
| تدمد: | 1945-7170 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ddba545d3d1578ad46a5fc1a39e2faTest https://doi.org/10.1210/en.2011-1081Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e2ddba545d3d1578ad46a5fc1a39e2fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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