Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes
| العنوان: | Myeloid-Derived Growth Factor Promotes Intestinal Glucagon-Like Peptide-1 Production in Male Mice With Type 2 Diabetes |
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| المؤلفون: | Lin Xiang, Guangda Xiang, Junxia Zhang, Min Liu, Bei Guo, Li Wang, Biao Zhu, Huan Li, Lingwei Xiang, Yan Ding, Biying Meng, Hui Zhao, Jing Dong, Yixiang Li, Jiajia Zhang |
| المصدر: | Endocrinology. 161 |
| بيانات النشر: | The Endocrine Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, MAPK/ERK pathway, medicine.medical_specialty, MAP Kinase Signaling System, medicine.medical_treatment, Incretin, Incretins, Cell Line, Diabetes Mellitus, Experimental, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, GSK-3, Internal medicine, medicine, Animals, Humans, Glucose homeostasis, Protein kinase A, Aged, Mice, Knockout, Chemistry, Kinase, Interleukins, Growth factor, Middle Aged, Glucagon-like peptide-1, 030104 developmental biology, Diabetes Mellitus, Type 2, Case-Control Studies, 030220 oncology & carcinogenesis |
| الوصف: | Myeloid-derived growth factor (MYDGF), which is produced by bone marrow–derived cells, mediates cardiac repair following myocardial infarction by inhibiting cardiac myocyte apoptosis to subsequently reduce the infarct size. However, the function of MYDGF in the incretin system of diabetes is still unknown. Here, loss-of-function and gain-of-function experiments in mice revealed that MYDGF maintains glucose homeostasis by inducing glucagon-like peptide-1 (GLP-1) production and secretion and that it improves glucose tolerance and lipid metabolism. Treatment with recombinant MYDGF increased the secretion and production of GLP-1 in STC-1 cells in vitro. Mechanistically, the positive effects of MYDGF are potentially attributable to the activation of protein kinase A/glycogen synthase kinase 3β/β-catenin (PKA/GSK-3β/β-catenin) and mitogen-activated protein kinase (MAPK) kinases/extracellular regulated protein kinase (MEK/ERK) pathways. Based on these findings, MYDGF promotes the secretion and production of GLP-1 in intestinal L-cells and potentially represents a potential therapeutic medication target for type 2 diabetes. |
| تدمد: | 1945-7170 0013-7227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d29536c48c610cf8c4b77f12a0559dTest https://doi.org/10.1210/endocr/bqaa003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....84d29536c48c610cf8c4b77f12a0559d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457170 00137227 |
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