التفاصيل البيبلوغرافية
| العنوان: |
cAMP PATHWAY ALTERATIONS FROM THE CELL SURFACE TO THE NUCLEUS IN ADRENOCORTICAL TUMORS. |
| المؤلفون: |
Rosenberg, Dan, Groussin, Lionel, Bertagna, Xavier, Bertherat, Jérôme |
| المصدر: |
Endocrine Research; Nov2002, Vol. 28 Issue 4, p765-775, 11p |
| مصطلحات موضوعية: |
CYCLIC adenylic acid, G proteins, ADRENOCORTICOTROPIC hormone, ADRENAL cortex |
| مستخلص: |
The cyclic AMP (cAMP) pathway plays a major role in the development of endocrine tissues and various molecular defects of key components of this pathway (G protein, receptors, PKA, …) have been observed in endocrine tumors. Hypersecretion of adrenocorticotropin hormone (ACTH), the key activator of the cAMP pathway in adrenal cortex, is associated with adrenocortical hyperplasia and cortisol oversecretion (Cushing's syndrome). The best example of «illegitimate» membrane receptors expression reported is the abnormal expression of the adenylyl cyclase activating gastric inhibitory peptide receptor (GIP-R) in ACTH-independent Cushing's syndrome (ACS). We have observed that ectopic expression of the GIP-R is frequent in ACTHIndependent Macronodular Adrenal Hyperplasia (AIMAH), rare in benign adrenal adenoma (AA), but seems absent in Adrenal Cancer (AC). In vivo systematic screening of AIMAH shows at least one abnormal response of cortisol (suggesting «illegitimate» membrane receptor expression) in almost all patients. Somatic and germ line inactivating mutations of PRKAR1 (regulatory subunit R1A of PKA) can be observed in patient with isolated primary pigmented nodular adrenocortical disease (PPNAD) and AA responsible for ACS. At the nuclear level, the cAMP pathway regulates transcription mainly by PKA-dependent phosphorylation of the cyclic AMP response element binding (CREB) family of transcription factors (CREB, CREM, and ATF-1). Cyclic AMP response element binding protein (CREB) is expressed in normal adrenal cortex. Alterations of CRE binding proteins with loss of CREB expression and compensatory overexpression of CREMtau is observed in the human adrenocortical cancer cell line H295R. Similar alterations are found at the protein level in human malignant adrenocortical tumors. In conclusion, various alterations leading to activation or inactivation of key components of the cAMP signaling pathway can be observed in adrenocortical... [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
