Silent Corticotroph Adenoma with Adrenal Cortical Choristoma: a Rare but Distinct Morphological Entity
| العنوان: | Silent Corticotroph Adenoma with Adrenal Cortical Choristoma: a Rare but Distinct Morphological Entity |
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| المؤلفون: | Thomas Ng, Sylvia L. Asa, Jacqueline McMaster, Darshika Christie-David, Ozgur Mete |
| المصدر: | Endocrine Pathology. 24:162-166 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adenoma, Adult, Male, Steroidogenic factor 1, medicine.medical_specialty, Pathology, Choristoma, Endocrinology, Diabetes and Metabolism, Adrenocorticotropic hormone, Biology, Pathology and Forensic Medicine, Endocrinology, Pituitary adenoma, Internal medicine, medicine, Humans, Adrenal cortex, General Medicine, medicine.disease, Immunohistochemistry, ACTH-Secreting Pituitary Adenoma, medicine.anatomical_structure, Adrenal Cortex, Corticotropic cell, Differential diagnosis, Calretinin |
| الوصف: | This report describes a case of pituitary adenoma with interspersed adrenal cortical cells. The pituitary cells were confirmed to be corticotrophs with Tpit and adrenocorticotropic hormone immunohistochemistry, whereas the adrenal cortical cells were verified to be such with steroidogenic factor-1 (SF-1), inhibin, calretinin, and Melan A staining. The presence of normal adrenal cortical cells in the heterotopic location of the sella fulfills the definition of choristoma. The origin of adrenal cortical cells within a pituitary adenoma remains unexplained. The important role of SF-1 in both pituitary and adrenal cortex may explain a relationship that supports the possibility of an abnormal proliferation and differentiation of uncommitted mesenchymal stem cells within the sella. However, it remains possible that misplaced adrenal cortical cells derived during embryogenesis give rise to this rare but distinct morphological entity that can pose a difficult diagnostic dilemma. The approach to differential diagnosis is discussed. |
| تدمد: | 1559-0097 1046-3976 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03bd1ccfefc9fd356519ea43b76d01bTest https://doi.org/10.1007/s12022-013-9256-9Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....c03bd1ccfefc9fd356519ea43b76d01b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590097 10463976 |
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