Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome
| العنوان: | Plasma plasminogen activator inhibitor-1 levels in the different phenotypes of the polycystic ovary syndrome |
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| المؤلفون: | Dimitrios Panidis, Ekaterini Koiou, Ilias Katsikis, Stylianos Mavridis, Konstantinos Dinas, Konstantinos Tziomalos, Eleni A. Kandaraki, Elena Tsourdi |
| المصدر: | Endocrine Journal. 59:21-29 |
| بيانات النشر: | Japan Endocrine Society, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Overweight, Body Mass Index, Cohort Studies, Anovulation, Young Adult, chemistry.chemical_compound, Endocrinology, Insulin resistance, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Obesity, Adiposity, business.industry, Hyperandrogenism, nutritional and metabolic diseases, medicine.disease, Polycystic ovary, female genital diseases and pregnancy complications, Phenotype, chemistry, Plasminogen activator inhibitor-1, Practice Guidelines as Topic, Female, Insulin Resistance, medicine.symptom, business, Body mass index, Biomarkers, Polycystic Ovary Syndrome |
| الوصف: | We aimed to evaluate plasma plasminogen activator inhibitor-1 (PAI-1) antigen levels in women with polycystic ovary syndrome (PCOS) and different levels of adiposity and PCOS phenotypes. We studied 199 women with PCOS and 50 age-matched healthy women divided in normal weight (n=100 and n=25, respectively) and overweight/obese (n=99 and n=25, respectively). Normal weight and overweight/obese patients with PCOS were further divided in patients diagnosed according to the 1990 criteria (i.e. with anovulation and hyperandrogenemia; 1990 criteria group) and in patients with the additional phenotypes introduced in 2003 (i.e. with polycystic ovaries and either anovulation or hyperandrogenemia; additional 2003 criteria group). In normal weight subjects, plasma PAI-1 levels did not differ between women with PCOS (regardless of group) and controls, or between the 1990 criteria and the additional 2003 criteria groups of PCOS. In overweight/obese subjects, plasma PAI-1 levels were higher in both the 1990 criteria and the additional 2003 criteria groups of PCOS compared with controls (p0.001 and p=0.004, respectively), but did not differ between the 1990 criteria and the additional 2003 criteria groups of PCOS. In conclusion, plasma PAI-1 levels are elevated in overweight/obese women with PCOS but not in normal weight women with this syndrome. Plasma PAI-1 levels do not differ between the phenotypes of PCOS. |
| تدمد: | 1348-4540 0918-8959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208acabb12f6ad1841e4e0d9adb2a6e5Test https://doi.org/10.1507/endocrj.ej11-0023Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....208acabb12f6ad1841e4e0d9adb2a6e5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13484540 09188959 |
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