المؤلفون: Zhiguang Zhou, Zhiguo Xie, Xiajie Shi, Shan Pan, Ting Wu, Gan Huang

المصدر: Endocrine Journal. 67:793-802

مصطلحات موضوعية: Male, endocrine system diseases, Tetraspanins, Endocrinology, Diabetes and Metabolism, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Child, geography.geographical_feature_category, biology, Glutamate Decarboxylase, Middle Aged, Islet, Organ Specificity, Child, Preschool, 030220 oncology & carcinogenesis, Female, Antibody, Adult, China, endocrine system, Adolescent, Nerve Tissue Proteins, 030209 endocrinology & metabolism, Zinc Transporter 8, Islets of Langerhans, Young Adult, 03 medical and health sciences, Antigen, GTP-Binding Proteins, Thyroid peroxidase, medicine, Humans, Protein Glutamine gamma Glutamyltransferase 2, Insulinoma, Aged, Autoantibodies, Type 1 diabetes, geography, Transglutaminases, business.industry, Autoantibody, Infant, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Case-Control Studies, Immunology, biology.protein, Steroid 21-Hydroxylase, Glycated hemoglobin, business

الوصف: This study aims to investigate the prevalence of islet autoantibodies and other organ-specific autoantibodies in type 1 diabetes mellitus (T1DM) patients and characterize their clinical features. Glutamic acid decarboxylase antibody (GADA), insulinoma antigen 2 antibody (IA-2A), zinc transporter 8 antibody (ZnT8A) and tetraspanin7 antibody (TSPAN7A) were assayed by radioligand or luciferase immunoprecipitation system assays in 205 newly diagnosed acute-onset T1DM patients and 170 healthy controls. Other organ-specific autoantibodies, including thyroid peroxidase antibody (TPOA), thyroglobulin antibody (TGA), tissue transglutaminase antibody (tTGA) and 21-hydroxylase antibody (21-OHA), were also measured. The prevalence of GADA, IA-2A, ZnT8A, TSPAN7A, TPOA, TGA and 21-OHA was higher in T1DM patients than in healthy controls. The combinational assay of various islet autoantibodies could increase the frequency of autoantibody positivity in T1DM to 85.4%. GADA+ IA-2A+ T1DM patients preferentially had TPOA and TGA, while IA-2A+ patients often had tTGA. Patients positive for two or more islet autoantibodies often had TPOA and TGA. BMI of multiple islet autoantibody-positive patients was lower than that of patients with single or no islet autoantibodies, and there were no significant differences in C-peptide and glycated hemoglobin between patients positive for islet autoantibodies combined with other organ-specific antibodies and noncombined patients. Younger female patients who were islet autoantibody positive were more likely to have TPOA and TGA. The frequency of Graves' disease was much higher in T1DM patients than in healthy controls. T1DM usually occurs together with other organ-specific autoantibodies. Measuring of other organ-specific autoantibodies will be beneficial for T1DM patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b253f1fd9d241545ff2a1d6359587f6Test
https://doi.org/10.1507/endocrj.ej20-0002Test

المؤلفون: Qian Wu, Yao Qin, Tao Yang, Xuqin Zheng, Heng Chen, Mei Zhang, Shuai Zheng

المصدر: Endocrine Journal. 67:827-840

مصطلحات موضوعية: Adult, Male, Oncology, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Mesenchymal Stem Cell Transplantation, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, Child, Type 1 diabetes, business.industry, Insulin, Mesenchymal stem cell, Hematopoietic Stem Cell Transplantation, Mesenchymal Stem Cells, Publication bias, Hematopoietic Stem Cells, medicine.disease, Transplantation, Haematopoiesis, Diabetes Mellitus, Type 1, Treatment Outcome, Child, Preschool, 030220 oncology & carcinogenesis, Meta-analysis, Female, Stem cell, business, Stem Cell Transplantation

الوصف: Stem cells (SCs) therapy is a new promising therapeutic modality for type 1 diabetes (T1DM). We performed a systematic review and meta-analysis to evaluate the efficacy and safety of stem cells transplantation (SCT) in patients with T1DM. We searched five literature databases (MEDLINE, EMBASE, Web of Science, WanFang and CENTRAL) up to 31 October 2019. 29 studies (487 patients with T1DM) were included in our meta-analysis. There was no substantial publication bias. Meta-analysis showed the SCT had significant effect to decrease HbA1c (SMD, 1.40; 95% CI, 0.93 to 1.86; p < 0.00001; I2 = 89%) and to improve C-peptide levels (SMD, -0.62; 95% CI, -1.22 to -0.02; p = 0.04; I2 = 92%) at 1 year follow-up. Subgroup analyses showed the heterogeneity level of the results was high. Significant improvement of metabolic outcomes was observed in the subgroups of mesenchymal stem cells (MSCs) combined with hematopoietic stem cells (HSCs) and HSCs. The older age showed significant association with the efficacy in HSCs subgroup. The higher GADA positive rate before treatment also significantly associated with the decrease of daily insulin requirement. The transient insulin independence rate at last follow-up was 9.6 per 100 person-years (95% CI: 5.8-13.5%). The mean length of insulin independence was 15.6 months (95% CI: 12.3-18.9). The mortality of SCT was 3.4% (95% CI: 2.1-5.5%). Therefore, SCT is an efficacious and safe method for treating patients with T1DM especially in the subgroups of MSCs + HSCs and HSCs. Well designed, double blind and randomized controlled trails with large sample size and long-term follow-up are needed for further ‍evaluation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238bd79bcca553607c0aec8e4bc69e66Test
https://doi.org/10.1507/endocrj.ej20-0050Test

المؤلفون: Mitsuhiko Noda, Kazuyuki Inoue, Gen Mizutani, Yoichi Oikawa, Ikuo Inoue, Masako Hatano, Akira Shimada, Daigo Saito

المصدر: Endocrine Journal. 66:329-336

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Fulminant, 030209 endocrinology & metabolism, Glutamic acid decarboxylase antibody, Gastroenterology, Body Mass Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, Insulin, Autoantibodies, Rank correlation, Type 1 diabetes, biology, Glutamate Decarboxylase, business.industry, Middle Aged, medicine.disease, Titer, Cross-Sectional Studies, Diabetes Mellitus, Type 1, 030220 oncology & carcinogenesis, biology.protein, Ketone bodies, Female, Symptom Assessment, Antibody, business, Body mass index

الوصف: This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. This cross-sectional observational study included 20 cases with GADA-positive fulminant type 1 diabetes (4 cases from our hospital and 16 from cases reported in the literature). The association between GADA titers and clinical parameters [age, sex, body weight, body mass index, period from appearance of any prodromal symptoms to diagnosis, period from development of hyperglycemic symptoms to diagnosis, GADA titer, HbA1c level, blood pH and HCO3- level, serum levels of ketone bodies and pancreatic exocrine enzymes] were analyzed. Spearman's rank correlation coefficient (rs) was used for the correlation analysis. The results showed that there was a significant inverse correlation between GADA titers and the "period from appearance of any prodromal symptoms to diagnosis" (rs = -0.559, p < 0.05). Moreover, GADA titers were inversely correlated with blood pH and HCO3- level (rs = -0.576, p < 0.05, rs = -0.578, p < 0.05, respectively), and positively correlated with serum levels of total ketone bodies, acetoacetate, and 3-hydroxybutyrate (rs = 0.661, p < 0.05; rs = 0.700, p < 0.05; and rs = 0.782, p < 0.01, respectively). These findings suggest that higher GADA titers may be linked to more severe clinical severity of GADA-positive fulminant type 1 diabetes at onset. This association may be attributed to possible pre-existence of autoimmunity-related β-cell damage before the onset of fulminant type 1 diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f90896c1fbbfe8104951ab95a418a5Test
https://doi.org/10.1507/endocrj.ej18-0417Test

المؤلفون: Toshihide Kawai, Kumiko Tanaka, Hajime Tanaka, Takeshi Katsuki, Nobuyuki Shimozawa, Naoko Amano, Tomohide Adachi

المصدر: Endocrine Journal. 67:655-658

مصطلحات موضوعية: Adult, Male, endocrine system, medicine.medical_specialty, Hydrocortisone, endocrine system diseases, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Physical examination, Anorexia, ATP Binding Cassette Transporter, Subfamily D, Member 1, Gastroenterology, Primary Adrenal Insufficiency, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Addison Disease, Internal medicine, Adrenal Glands, medicine, Humans, Young adult, Adrenoleukodystrophy, Glucocorticoids, medicine.diagnostic_test, business.industry, Brain, medicine.disease, Hyperintensity, Early Diagnosis, 030220 oncology & carcinogenesis, Addison's disease, medicine.symptom, business, Glucocorticoid, medicine.drug

الوصف: Adrenoleukodystrophy (ALD) is an X-linked disorder caused by a hemizygous mutation of the ABCD1 gene. Patients with ALD show progressive central nervous system demyelination and primary adrenal insufficiency. In Japan, most reported ALD cases were childhood-onset, and only one case of an adult patient with Addison's disease form of ALD has ever been reported. Herein, we present a case of a 29-year-old man with Addison's disease form of ALD. The patient had anorexia, weight loss, and skin pigmentation from 18 years of age. At first visit, his weight had decreased by 12 kg from 57 kg when he was 15 years old. Endocrinological examination showed low serum cortisol (1.2 μg/dL) with high plasma ACTH (4,750 pg/mL), and abdominal computed tomography showed normal adrenal glands. Very-long-chain fatty acid (VLCFA) levels were elevated, and the ABCD1 mutation, p.Gly116Arg, was identified in hemizygous state. He had no significant neurological findings on physical examination and no white matter lesions on brain magnetic resonance imaging (MRI). He was diagnosed with ALD presenting as Addison's disease, and glucocorticoid replacement therapy was initiated. Four years after the diagnosis, he still did not show any neurological findings and any white matter lesions on brain MRI. Evaluating VLCFA levels for ALD diagnosis is important in young adult men with idiopathic primary adrenal insufficiency as well as in children. Early diagnosis enables more rational approaches including the early detection of neurological complications and might improve the prognosis of patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50719ac54629e403f52275e05d2b9211Test
https://doi.org/10.1507/endocrj.ej19-0576Test

المؤلفون: Masako Aoki, Junichi Suzuki, Remi Kuwabara, Misako Okuno, Tatsuhiko Urakami

المصدر: Endocrine Journal. 63:159-167

مصطلحات موضوعية: Adult, Blood Glucose, Male, Insulin degludec, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin Glargine, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Hypoglycemia, Gastroenterology, Drug Administration Schedule, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, Humans, Medicine, Circadian rhythm, Young adult, Glycated Hemoglobin, Type 1 diabetes, Drug Substitution, business.industry, Insulin glargine, Insulin, medicine.disease, Circadian Rhythm, Insulin, Long-Acting, Diabetes Mellitus, Type 1, Treatment Outcome, Female, business, medicine.drug

الوصف: We evaluated the efficacy and safety of switching to insulin degludec (IDeg) from insulin glargine (IGlar) as basal-bolus therapy in young people with type 1 diabetes. The subjects were 36 patients, 21.3±1.0 years of age, with type 1 diabetes. IGlar had previously been injected once daily in 25 patients and twice daily in 11. They were then switched from IGlar to once-daily injection of IDeg. Both fasting plasma glucose (FPG) and HbA1c levels decreased significantly from 134±3.9 mg/dL and 7.9±0.2% at baseline to 116±2.2 mg/dL and 7.4±0.2% at 12 months after starting IDeg (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3d28fb4e08cdf987400adb58edda3bTest
https://doi.org/10.1507/endocrj.ej15-0245Test

المؤلفون: Iichiro Shimomura, Eiichi Morii, Toshimitsu Hamasaki, Yukiko Tabuchi, Yugo Miyata, Youichi Saitoh, Atsunori Fukuhara, Michio Otsuki, Satoru Oshino, Kosuke Mukai, Tetsuhiro Kitamura, Toshiharu Onodera

المصدر: Endocrine Journal. 63:545-554

مصطلحات موضوعية: Adenoma, Adult, Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Gene Expression, Prohormone convertase, 030209 endocrinology & metabolism, Adrenocorticotropic hormone, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glucocorticoid receptor, Adrenocorticotropic Hormone, Internal medicine, Nuclear Receptor Subfamily 4, Group A, Member 1, medicine, Humans, Pituitary ACTH Hypersecretion, Aged, Feedback, Physiological, Secretory Pathway, business.industry, Pituitary ACTH hypersecretion, Pituitary tumors, Cushing's disease, Middle Aged, medicine.disease, ACTH-Secreting Pituitary Adenoma, 030104 developmental biology, Hormone receptor, Case-Control Studies, Asymptomatic Diseases, Female, business, hormones, hormone substitutes, and hormone antagonists

الوصف: Cushing's disease (CD) and subclinical Cushing's disease (subCD) are both diseases caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. However, ACTH autonomy in subCD is weaker than in CD and there are no Cushingoid features in subCD. The differences of molecular mechanisms in ACTH autonomy between CD and subCD have not yet been reported. Therefore, we aimed to investigate the differences in molecular mechanisms of ACTH-secretion autonomy between CD and subCD. The study included 23 patients [7 CD, 6 subCD, and 10 non-functioning pituitary tumors (NFTs)] who underwent transsphenoidal surgery at the Osaka University Hospital between December 2009 and October 2013. Using quantitative real-time PCR, various ACTH-related gene expressions in tumor tissues from CD, subCD, and NFT were measured such as pro-opiomelanocortin (POMC), POMC transcription factor (Tpit, Pitx1, NeuroD1, and Nur77), POMC peptide processing enzymes (prohormone convertase: PC1/3 and PC2), and ACTH secretion-related factors (corticotropin-releasing hormone receptor 1: CRHR1 and glucocorticoid receptor α: GRα). Only Nur77 mRNA levels were significantly higher in CD than in subCD. Furthermore, we stained 6 CD and 6 subCD with anti-Nur77 antibody. All tumor samples from CD had Nur77 protein positive cells. On the other hand, Nur77 protein was expressed in only one tumor sample from subCD. This sample showed high expression of Nur77 mRNA. Nur77 is an important to regulate POMC transcription and negative-feedback by glucocorticoids. Nur77 gene expression levels might involve different autonomy of ACTH production between CD and subCD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae424ee0c191af5e9ac2e570560b568Test
https://doi.org/10.1507/endocrj.ej15-0695Test

المؤلفون: Takashi Nakamura, Aya Kadota, Atsushi Ohnishi, Hiroshi Maegawa, Motozumi Okamoto, Katsuyuki Miura, Itsuko Miyazawa, Tsuyoshi Ikai

المصدر: Endocrine journal. 65(5)

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Overweight, Body Mass Index, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Japan, Internal medicine, Diabetes mellitus, medicine, Prevalence, Humans, 030212 general & internal medicine, Obesity, Glycemic, Aged, Aged, 80 and over, Glycated Hemoglobin, medicine.diagnostic_test, business.industry, Body Weight, Middle Aged, medicine.disease, Health Surveys, Lipids, Blood pressure, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Albuminuria, Female, medicine.symptom, business, Lipid profile, Body mass index

الوصف: The prevalence of obesity is increasing globally in patients with diabetes. This study aimed to examine 12-year trends of increasing obesity in Japanese patients with diabetes, and their clinical features. The study used results of the Shiga Diabetes Clinical Survey, which recorded medical performance in diabetic patients in 2000, 2006 and 2012. Data were analyzed from 14,205, 14,407 and 21,449 adult patients in these three years, respectively. Overweight and obesity prevalence and the clinical features of diabetes patients were examined, stratified by body mass index (BMI) and age. The prevalence of overweight (BMI 25-30 kg/m2) and obesity (BMI ≥30 kg/m2) were 27.0% and 5.1% in 2000, 28.9% and 7.3% in 2006 and 30.9% and 10.0% in 2012. Glycemic control, blood pressure and serum lipid profile improved over 12 years in all BMI categories. However, glycemic and triglyceride control were insufficient in obese patients aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c620342260f2d0c0dc94fb7d6ef8bb3dTest
https://pubmed.ncbi.nlm.nih.gov/33642456Test

المؤلفون: Agustín Ángel Merchante-Alfaro, Olalla Rubio-Puchol, Susana Pérez-Naranjo, Pablo Abellán-Galiana

المصدر: Endocrine Journal. 63:411-412

مصطلحات موضوعية: Adult, Blood Glucose, Male, Insulin degludec, medicine.medical_specialty, Letter to the editor, Long acting insulin, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Hypoglycemia, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Young adult, Type 1 diabetes, business.industry, Middle Aged, medicine.disease, Insulin, Long-Acting, Diabetes Mellitus, Type 1, Spain, Female, business, Cohort study

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24149e622455a2a8fb8028e19b6c27c5Test
https://doi.org/10.1507/endocrj.ej16-0094Test