Effects of the selective GPER1 agonist G1 on bone growth
| العنوان: | Effects of the selective GPER1 agonist G1 on bone growth |
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| المؤلفون: | Lars Sävendahl, Claes Ohlsson, Maryam Iravani, Elham Karimian, Andrei S. Chagin, Marie K Lagerquist |
| المصدر: | Endocrine Connections, Vol 8, Iss 9, Pp 1302-1309 (2019) Endocrine Connections |
| بيانات النشر: | Bioscientifica, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Agonist, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, growth, chondrocytes, Estrogen receptor, 030209 endocrinology & metabolism, Stimulation, bone, lcsh:Diseases of the endocrine glands. Clinical endocrinology, GPER1, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, growth plate, G1, Internal Medicine, medicine, estrogen, Bone growth, lcsh:RC648-665, business.industry, Research, 030104 developmental biology, Estrogen, Ovariectomized rat, business, Estrogen receptor alpha, Ex vivo |
| الوصف: | Estrogens may affect bone growth locally or systemically via the known estrogen receptors ESR1, ESR2 and G protein-coupled estrogen receptor 1 (GPER1). Mouse and human growth plate chondrocytes have been demonstrated to express GPER1 and ablation of this receptor increased bone length in mice. Therefore, GPER1 is an attractive target for therapeutic modulation of bone growth, which has never been explored. To investigate the effects of activated GPER1 on the growth plate, we locally exposed mouse metatarsal bones to different concentrations of the selective GPER1 agonist G1 for 14 days ex vivo. The results showed that none of the concentrations of G1 had any direct effect on metatarsal bone growth when compared to control. To evaluate if GPER1 stimulation may systemically modulate bone growth, ovariectomized C57BL/6 mice were treated with G1 or β-estradiol (E2). Similarly, G1 did not influence tibia and femur growth in treated mice. As expected, E2 treatment suppressed bone growth in vivo. We conclude that ligand stimulation of GPER1 does not influence bone growth in mice. |
| اللغة: | English |
| تدمد: | 2049-3614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5069d2c8e50e84650d0a9dda6b7a85Test https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-0274.xmlTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7a5069d2c8e50e84650d0a9dda6b7a85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20493614 |
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