دورية
Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism
| العنوان: | Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism |
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| المؤلفون: | Wu, Wenjun, Zhou, Qi, Xu, Shihao, An, Siqin, Shen, Feixia, Li, Huanbin, Gong, Xiaohua, Chen, Xiaojun |
| المصدر: | Endocrine; February 2021, Vol. 71 Issue: 2 p476-483, 8p |
| مستخلص: | Purpose: To investigate the changes of the serum parathyroid hormone (PTH) and calcium level, as well as bone mineral density (BMD), after percutaneous ultrasound-guided microwave ablation (MWA) for primary hyperparathyroidism (pHPT) caused by single hyperfunctional nodule. Methods: The study enrolled 20 patients with a total of 20 nodules of MWA treatment to pHPT in one session. The normalization rate of the serum PTH and calcium was evaluated at every 6 months during 2-year follow-up after MWA. The bone mineral density (BMD) at lumbar spine and femoral neck were also compared before and after the procedure. Results: The normalization rate of both PTH and serum calcium at 6-, 12-, 24-month follow-up was 66.6%, 80.0%, and 62.5%, respectively. Though the normalization rate of serum calcium level at 6-, 12-, and 24-month visit after MWA was 100%. The BMD increased 12, 24 months after MWA at lumbar spine (1.022?±?0.155, 1.057?±?0.151 vs 0.965?±?0.145?g/cm2, p?<?0.01) and femoral neck at 2-year assessment (0.819?±?0.094 vs 0.771?±?0.102?g/cm2, p?=?0.015). Seven nodules disappeared in 20 nodules (35.0%), average ablation time was 122.29?±?107.54?s (34–460?s). Six patients encountered voice change during the procedure, one participant was confirmed recurrent laryngeal injuries but recovered within 2 months. Conclusions: Percutaneous ultrasound-guided microwave ablation results in improvement of biochemical profiles and bone mineral density in subjects with single hyperfunctional parathyroid nodule. However, the long-term efficacy of the MWA remains to be verified. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 1355008x 15590100 |
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| DOI: | 10.1007/s12020-020-02511-1 |