Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
| العنوان: | Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil |
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| المؤلفون: | Carolina Q. Sacramento, Vinicius Cardoso Soares, Felipe Betoni Saraiva, Diogo A. Tschoeke, Marcelo Alves Ferreira, Aline de Paula Dias Da Silva, Danielle A. S. Rodrigues, Isaclaudia G. de Azevedo, Patrícia T. Bozza, João Gesto, Natalia Fintelman-Rodrigues, Fernando A. Bozza, Thiago Moreno L. Souza, Andre M. Vale, Monique Cristina dos Santos, Hui Jiang, Carlos M. Morel, Hongdong Tan |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1446-1453 (2021) |
| بيانات النشر: | Centers for Disease Control and Prevention, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), Epidemiology, viruses, 030231 tropical medicine, Infectious and parasitic diseases, RC109-216, Disease, medicine.disease_cause, Disease cluster, reinfection, 03 medical and health sciences, respiratory infections, 0302 clinical medicine, Immune system, Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil, Medicine, Humans, 030212 general & internal medicine, Coronavirus, First episode, business.industry, Host (biology), SARS-CoV-2, Research, COVID-19, zoonoses, Immunity, Humoral, Infectious Diseases, coronavirus disease, Humoral immunity, Immunology, next-generation sequencing, business, Viral load, humoral response, Brazil, severe acute respiratory syndrome coronavirus 2 |
| الوصف: | The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented. |
| اللغة: | English |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7c38c1127fdcf28b034e5619ae5b4d8Test http://europepmc.org/articles/PMC8084520Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c7c38c1127fdcf28b034e5619ae5b4d8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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