التفاصيل البيبلوغرافية
| العنوان: |
Novel Assay to Measure Seroprevalence of Zika Virus in the Philippines. |
| المؤلفون: |
Adams, Cameron1, Jadi, Ramesh1, Segovia-Chumbez, Bruno1, Daag, Jedas2, Ylade, Michelle2, Medina, Freddy A.3, Sharp, Tyler M.3, Munoz-Jordan, Jorge L.3, In-Kyu Yoon4, Deen, Jacqueline2, Lopez, Anna Lena2, de Silva, Aravinda M.1 aravinda_desilva@med.unc.edu, Premkumar, Lakshmanane1 prem@med.unc.edu, Yoon, In-Kyu (AUTHOR) |
| المصدر: |
Emerging Infectious Diseases. Dec2021, Vol. 27 Issue 12, p3073-3081. 9p. |
| مصطلحات موضوعية: |
*ZIKA virus, *SEROPREVALENCE, *DENGUE viruses, *FLAVIVIRUSES, *SEROTYPES, *ANTIGEN-antibody reactions, *RESEARCH, *DENGUE, *RESEARCH methodology, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *RESEARCH funding, *VIRAL antibodies, *EPIDEMIOLOGICAL research |
| مصطلحات جغرافية: |
PHILIPPINES |
| مستخلص: |
Zika virus (ZIKV) is a member of the Flaviviridae family, which includes other clinically notable viruses such as the 4 dengue virus serotypes (DENV-1-4). Distinguishing DENVs from ZIKV using the established serologic assays widely used for monitoring DENV transmission is difficult because of antibody cross-reactivity between these closely related flaviviruses. We describe a modified and improved recombinant envelope domain III-based serologic assay for detecting ZIKV type-specific antibodies in regions with endemic DENV transmission. When the assay was used to measure ZIKV seroprevalence in 2017 among children 9-14 years of age living in a region of the Philippines with endemic DENV transmission, we observed a ZIKV seroprevalence of 18%. Investigators should consider using the ZIKV envelope domain III-based assay, which is simple and readily adaptable for use in standard clinical and public health laboratories, to assess ZIKV seroprevalence in areas with endemic DENV transmission. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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