Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma
| العنوان: | Tumour inflammasome-derived IL-1β recruits neutrophils and improves local recurrence-free survival in EBV-induced nasopharyngeal carcinoma |
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| المؤلفون: | Yu-Sun Chang, David M. Ojcius, Nang-Ming Tsang, Li-Jie Wang, Chia-Chun Chen, Chun-Nan OuYang, Ying Liang, Chuen Hsueh, Lih-Chyang Chen, Kai-Ping Chang, Chiu-Chin Chen |
| المصدر: | EMBO Molecular Medicine |
| بيانات النشر: | WILEY-VCH Verlag, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Herpesvirus 4, Human, Inflammasomes, Neutrophils, Interleukin-1beta, Nasopharyngeal neoplasm, Inflammation, Mice, Inbred Strains, Biology, medicine.disease_cause, Cohort Studies, AIM2, Mice, inflammasome, medicine, Carcinoma, cancer, Animals, Humans, Research Articles, Retrospective Studies, therapy, Nasopharyngeal Carcinoma, Cancer, neutrophil, Inflammasome, Nasopharyngeal Neoplasms, medicine.disease, Mice, Inbred C57BL, Nasopharyngeal carcinoma, Neutrophil Infiltration, Immunology, Molecular Medicine, prognosis, medicine.symptom, Carcinogenesis, Reactive Oxygen Species, medicine.drug |
| الوصف: | Inflammasomes sense infection and cellular damage and are critical for triggering inflammation through IL-1β production. In carcinogenesis, inflammasomes may have contradictory roles through facilitating antitumour immunity and inducing oncogenic factors. Their function in cancer remains poorly characterized. Here we show that the NLRP3, AIM2 and RIG-I inflammasomes are overexpressed in Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC), and expression levels correlate with patient survival. In tumour cells, AIM2 and RIG-I are required for IL-1β induction by EBV genomic DNA and EBV-encoded small RNAs, respectively, while NLRP3 responds to extracellular ATP and reactive oxygen species. Irradiation and chemotherapy can further activate AIM2 and NLRP3, respectively. In mice, tumour-derived IL-1β inhibits tumour growth and enhances survival through host responses. Mechanistically, IL-1β-mediated anti-tumour effects depend on infiltrated immunostimulatory neutrophils. We show further that presence of tumour-associated neutrophils is significantly associated with better survival in NPC patients. Thus, tumour inflammasomes play a key role in tumour control by recruiting neutrophils, and their expression levels are favourable prognostic markers and promising therapeutic targets in patients. |
| اللغة: | English |
| تدمد: | 1757-4684 1757-4676 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4d512e0cb600422cb3174581f38c34Test http://europepmc.org/articles/PMC3531603Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3f4d512e0cb600422cb3174581f38c34 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17574684 17574676 |
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