دورية
Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin‐SV40 T antigen genes.
| العنوان: | Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin‐SV40 T antigen genes. |
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| المؤلفون: | Efrat, S., Baekkeskov, S., Lane, D., Hanahan, D. |
| المصدر: | EMBO Journal; September 1987, Vol. 6 Issue: 9 p2699-2704, 6p |
| مستخلص: | The expression of p53 has been evaluated during oncogenesis of the pancreatic beta cells in transgenic mice harboring hybrid insulin‐SV40 T antigen genes. Significant levels of p53 are detected in all cells expressing large T antigen. In contrast, the protein is undetectable in normal beta cells. There is a complete correspondence between the onset of expression of T antigen and the appearance of the endogenous p53 protein. In tumors, the two proteins are found in a complex. In addition, free uncomplexed T antigen is detected in every cell which expresses the transgene. These results are consistent with the participation of p53 in T antigen‐induced tumorigenesis in vivo. The early appearance of p53 in all beta cells expressing large T cannot readily explain the progression of a small fraction of these cells into solid tumors. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 02614189 14602075 |
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| DOI: | 10.1002/j.1460-2075.1987.tb02562.x |