دورية أكاديمية
Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness
| العنوان: | Acute control of the sleep switch in Drosophila reveals a role for gap junctions in regulating behavioral responsiveness |
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| المؤلفون: | Troup, Michael, Yap, Melvyn HW, Rohrscheib, Chelsie, Grabowska, Martyna J, Ertekin, Deniz, Randeniya, Roshini, Kottler, Benjamin, Larkin, Aoife, Munro, Kelly, Shaw, Paul J, van Swinderen, Bruno |
| المساهمون: | National Institutes of Health, National Health and Medical Research Council |
| المصدر: | eLife ; volume 7 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2018 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Sleep is a dynamic process in most animals, involving distinct stages that probably perform multiple functions for the brain. Before sleep functions can be initiated, it is likely that behavioral responsiveness to the outside world needs to be reduced, even while the animal is still awake. Recent work in Drosophila has uncovered a sleep switch in the dorsal fan-shaped body (dFB) of the fly’s central brain, but it is not known whether these sleep-promoting neurons also govern the acute need to ignore salient stimuli in the environment during sleep transitions. We found that optogenetic activation of the sleep switch suppressed behavioral responsiveness to mechanical stimuli, even in awake flies, indicating a broader role for these neurons in regulating arousal. The dFB-mediated suppression mechanism and its associated neural correlates requires innexin6 expression, suggesting that the acute need to reduce sensory perception when flies fall asleep is mediated in part by electrical synapses. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.37105 |
| الإتاحة: | https://doi.org/10.7554/elife.37105Test https://cdn.elifesciences.org/articles/37105/elife-37105-v2.pdfTest https://cdn.elifesciences.org/articles/37105/elife-37105-v2.xmlTest https://elifesciences.org/articles/37105Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.6B71D57F |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.37105 |
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