دورية أكاديمية
Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells
| العنوان: | Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells |
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| المؤلفون: | Marroqui, Laura, Lopes, Miguel, dos Santos, Reinaldo S, Grieco, Fabio A, Roivainen, Merja, Richardson, Sarah J, Morgan, Noel G, Op de beeck, Anne, Eizirik, Decio L |
| المساهمون: | Fonds De La Recherche Scientifique - FNRS, European Commission (EC), Fédération Wallonie-Bruxelles, Governo Brasil, Juvenile Diabetes Research Foundation International (JDRF) |
| المصدر: | eLife ; volume 4 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2015 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Type 1 diabetes (T1D) is an autoimmune disease caused by loss of pancreatic β cells via apoptosis while neighboring α cells are preserved. Viral infections by coxsackieviruses (CVB) may contribute to trigger autoimmunity in T1D. Cellular permissiveness to viral infection is modulated by innate antiviral responses, which vary among different cell types. We presently describe that global gene expression is similar in cytokine-treated and virus-infected human islet cells, with up-regulation of gene networks involved in cell autonomous immune responses. Comparison between the responses of rat pancreatic α and β cells to infection by CVB5 and 4 indicate that α cells trigger a more efficient antiviral response than β cells, including higher basal and induced expression of STAT1-regulated genes, and are thus better able to clear viral infections than β cells. These differences may explain why pancreatic β cells, but not α cells, are targeted by an autoimmune response during T1D. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.06990 |
| DOI: | 10.7554/eLife.06990 |
| الإتاحة: | https://doi.org/10.7554/elife.06990Test https://cdn.elifesciences.org/articles/06990/elife-06990-v2.pdfTest https://cdn.elifesciences.org/articles/06990/elife-06990-v2.xmlTest https://elifesciences.org/articles/06990Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.3BD6D6B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.06990 |
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