دورية أكاديمية
Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer
| العنوان: | Infrared molecular fingerprinting of blood-based liquid biopsies for the detection of cancer |
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| المؤلفون: | Huber, Marinus, Kepesidis, Kosmas V, Voronina, Liudmila, Fleischmann, Frank, Fill, Ernst, Hermann, Jacqueline, Koch, Ina, Milger-Kneidinger, Katrin, Kolben, Thomas, Schulz, Gerald B, Jokisch, Friedrich, Behr, Jürgen, Harbeck, Nadia, Reiser, Maximilian, Stief, Christian, Krausz, Ferenc, Zigman, Mihaela |
| المصدر: | eLife ; volume 10 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2021 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | Recent omics analyses of human biofluids provide opportunities to probe selected species of biomolecules for disease diagnostics. Fourier-transform infrared (FTIR) spectroscopy investigates the full repertoire of molecular species within a sample at once. Here, we present a multi-institutional study in which we analysed infrared fingerprints of plasma and serum samples from 1639 individuals with different solid tumours and carefully matched symptomatic and non-symptomatic reference individuals. Focusing on breast, bladder, prostate, and lung cancer, we find that infrared molecular fingerprinting is capable of detecting cancer: training a support vector machine algorithm allowed us to obtain binary classification performance in the range of 0.78–0.89 (area under the receiver operating characteristic curve [AUC]), with a clear correlation between AUC and tumour load. Intriguingly, we find that the spectral signatures differ between different cancer types. This study lays the foundation for high-throughput onco-IR-phenotyping of four common cancers, providing a cost-effective, complementary analytical tool for disease recognition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.68758 |
| الإتاحة: | https://doi.org/10.7554/elife.68758Test https://cdn.elifesciences.org/articles/68758/elife-68758-v1.pdfTest https://cdn.elifesciences.org/articles/68758/elife-68758-v1.xmlTest https://elifesciences.org/articles/68758Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.FCB9BE13 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7554/elife.68758 |
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