التفاصيل البيبلوغرافية
| العنوان: |
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. |
| المؤلفون: |
Ji, Daisy X.1, Witt, Kristen C.1, Kotov, Dmitri I.1,2, Margolis, Shally R.1, Louie, Alexander1, Chevée, Victoria1, Chen, Katherine J.1,2, Gaidt, Moritz M.1, Dhaliwal, Harmandeep S.3, Lee, Angus Y.3, Nishimura, Stephen L.4, Zamboni, Dario S.5, Kramnik, Igor6,7, Portnoy, Daniel A.1,8,9, Darwin, K. Heran10, Vance, Russell E.1,2,3 rvance@berkeley.edu |
| المصدر: |
eLife. 7/1/2021, p1-22. 22p. |
| مصطلحات موضوعية: |
*TYPE I interferons, *BACTERIAL diseases, *DRUG resistance in bacteria, *TUBERCULOSIS, *MYCOBACTERIAL diseases, *LEGIONELLA pneumophila, *VIRUS diseases |
| مستخلص: |
Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we provide evidence that Sp140 is a gene encoded within the Sst1 locus that represses type I IFN transcription during bacterial infections. We generated Sp140-/- mice and found that they are susceptible to infection by Legionella pneumophila and Mycobacterium tuberculosis. Susceptibility of Sp140-/- mice to bacterial infection was rescued by crosses to mice lacking the type I IFN receptor (Ifnar-/-). Our results implicate Sp140 as an important negative regulator of type I IFNs that is essential for resistance to bacterial infections. [ABSTRACT FROM AUTHOR] |
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