SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants
| العنوان: | SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants |
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| المؤلفون: | Mair, Andrea, Pedrotti, Lorenzo, Wurzinger, Bernhard, Anrather, Dorothea, Simeunovic, Andrea, Weiste, Christoph, Valerio, Concetta, Dietrich, Katrin, Kirchler, Tobias, Nägele, Thomas, Vicente Carbajosa, Jesús, Hanson, Johannes, 1969, Baena-González, Elena, Chaban, Christina, Weckwerth, Wolfram, Dröge-Laser, Wolfgang, Teige, Markus |
| المصدر: | eLIFE. 4 |
| الوصف: | Metabolic adjustment to changing environmental conditions, particularly balancing of growth and defense responses, is crucial for all organisms to survive. The evolutionary conserved AMPK/Snf1/SnRK1 kinases are well-known metabolic master regulators in the low-energy response in animals, yeast and plants. They act at two different levels: by modulating the activity of key metabolic enzymes, and by massive transcriptional reprogramming. While the first part is well established, the latter function is only partially understood in animals and not at all in plants. Here we identified the Arabidopsis transcription factor bZIP63 as key regulator of the starvation response and direct target of the SnRK1 kinase. Phosphorylation of bZIP63 by SnRK1 changed its dimerization preference, thereby affecting target gene expression and ultimately primary metabolism. A bzip63 knock-out mutant exhibited starvation-related phenotypes, which could be functionally complemented by wild type bZIP63, but not by a version harboring point mutations in the identified SnRK1 target sites. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-114426Test https://doi.org/10.7554/eLife.05828Test https://umu.diva-portal.org/smash/get/diva2:895333/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.05828 |