التفاصيل البيبلوغرافية
| العنوان: |
Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe. |
| المؤلفون: |
Souto, Daniel Garcia1,2,3 daniel.garcia.souto@usc.es, Bruzos, Alicia L.1,2, Diaz, Seila1, Rocha, Sara4, Valtierra, Ana Pequeño1, Lewis, Camila F. Roman5, Alonso, Juana5,6, Rodriguez, Rosana7, Costas, Damian7, Castro, Jorge Rodriguez1, Villanueva, Antonio7, Silva, Luis8, Valencia, Jose Maria9,10, Annona, Giovanni11, Tarallo, Andrea11, Ricardo, Fernando12, Cetinić, Ana Bratoš13, Posada, David5,6,14, Pasantes, Juan Jose14,15, Tubio, Jose MC1,2 jose.mc.tubio@usc.es |
| المصدر: |
eLife. 1/18/2022, p1-19. 19p. |
| مصطلحات موضوعية: |
*NUCLEOTIDE sequencing, *HAPLOTYPES, *CLAMS, *MARINE biodiversity, *MITOCHONDRIA, *SPECIES, *LEUKEMIA |
| مصطلحات جغرافية: |
SPAIN, EUROPE |
| مستخلص: |
Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia- like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole- genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe. [ABSTRACT FROM AUTHOR] |
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