دورية أكاديمية
IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses
| العنوان: | IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses |
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| المؤلفون: | Rachel A Gottschalk, Michael G Dorrington, Bhaskar Dutta, Kathleen S Krauss, Andrew J Martins, Stefan Uderhardt, Waipan Chan, John S Tsang, Parizad Torabi-Parizi, Iain DC Fraser, Ronald N Germain |
| المصدر: | eLife, Vol 8 (2019) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | inflammation, macrophage, type I IFN, negative feedback, signal integration, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophages with a titration matrix of TLR ligand pairs, we identified distinct stimulus requirements for activating and inhibitory events that evoked diverse cytokine production dynamics. These regulatory events were linked to patterns of inflammatory responses that distinguished between Gram-positive and Gram-negative bacteria, both in vitro and after in vivo lung infection. Stimulation beyond a TLR4 threshold and Gram-negative bacteria-induced responses were characterized by a rapid type I IFN-dependent decline in inflammatory cytokine production, independent of IL-10, whereas inflammatory responses to Gram-positive species were more sustained due to the absence of this IFN-dependent regulation. Thus, disparate triggering of a cytokine negative feedback loop promotes tuning of macrophage responses in a bacteria class-specific manner and provides context-dependent regulation of inflammation dynamics. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/46836Test; https://doaj.org/toc/2050-084XTest |
| DOI: | 10.7554/eLife.46836 |
| الوصول الحر: | https://doaj.org/article/fdc88cf2aeb74de0b9da323df06719f1Test |
| رقم الانضمام: | edsdoj.fdc88cf2aeb74de0b9da323df06719f1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.46836 |