A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants
| العنوان: | A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants |
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| المؤلفون: | Monique I. J. Spronken, Anjana C. Karawita, Alexander A. Khromykh, Keng Yih Chew, Cassandra L. Pegg, Lauren E. Steele, Kirsty R. Short, Myrna J. M. Bunte, Simon Phipps, Yin Xiang Setoh, Nathalie A. J. Verzele, Katina D. Hulme, Kyle R. Upton, Helle Bielefeldt-Ohmann, Conor J. Bloxham, Silvie Van den Hoecke, Bram Vrancken, Maria B. Sukkar |
| المساهمون: | Virology |
| المصدر: | eLife, Vol 10 (2021) eLife eLife, 10:e61803, 1-21. eLife Sciences Publications |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Mouse, viruses, Receptor for Advanced Glycation End Products, 0601 Biochemistry and Cell Biology, medicine.disease_cause, influenza virus, immunology, Mice, Immunology and Inflammation, Influenza A Virus, H1N1 Subtype, Interferon, Biology (General), Coronavirus, Mutation, Microbiology and Infectious Disease, General Neuroscience, General Medicine, 3. Good health, interferons, host-pathogen evolution, Host-Pathogen Interactions, Medicine, Female, medicine.drug, Research Article, Human, QH301-705.5, infectious disease, Science, 030106 microbiology, Virulence, Biology, General Biochemistry, Genetics and Molecular Biology, Virus, 03 medical and health sciences, Orthomyxoviridae Infections, medicine, Animals, human, mouse, Asthma, General Immunology and Microbiology, microbiology, COVID-19, asthma, Type I interferon production, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, inflammation, Infectious disease (medical specialty), Immunology, mutation |
| الوصف: | Influenza virus has a high mutation rate, such that within one host different viral variants can emerge. Evidence suggests that influenza virus variants are more prevalent in pregnant and/or obese individuals due to their impaired interferon response. We have recently shown that the non-allergic, paucigranulocytic subtype of asthma is associated with impaired type I interferon production. Here, we seek to address if this is associated with an increased emergence of influenza virus variants. Compared to controls, mice with paucigranulocytic asthma had increased disease severity and an increased emergence of influenza virus variants. Specifically, PB1 mutations exclusively detected in asthmatic mice were associated with increased polymerase activity. Furthermore, asthmatic host-derived virus led to increased disease severity in wild-type mice. Taken together, these data suggest that at least a subset of patients with asthma may be more susceptible to severe influenza and may be a possible source of new influenza virus variants. ispartof: ELIFE vol:10 ispartof: location:England status: published |
| وصف الملف: | application/pdf; Electronic |
| اللغة: | English |
| تدمد: | 2050-084X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341c42c431fa162d9b26f731140706d5Test https://doi.org/10.7554/elife.61803Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....341c42c431fa162d9b26f731140706d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2050084X |
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