دورية أكاديمية
Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population
| العنوان: | Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population |
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| المؤلفون: | Claudine Vasseur, Loïse Serra, Souleiman El Balkhi, Gaëlle Lefort, Christelle Ramé, Pascal Froment, Joëlle Dupont |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 278, Iss , Pp 116410- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | Human, Sperm parameters, Pesticide, Glyphosate, AMPA, 8OH-dG, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Environmental exposure to endocrine disruptors, such as pesticides, could contribute to a decline of human fertility. Glyphosate (GLY) is the main component of Glyphosate Based Herbicides (GBHs), which are the most commonly herbicides used in the world. Various animal model studies demonstrated its reprotoxicity. In Europe, GLY authorization in agriculture has been extended until 2034. Meanwhile the toxicity of GLY in humans is still in debate. The aims of our study were firstly to analyse the concentration of GLY and its main metabolite, amino-methyl-phosphonic acid (AMPA) by LC/MS-MS in the seminal and blood plasma in an infertile French men population (n=128). We secondly determined Total Antioxidant Status (TAS) and Total Oxidant Status (TOS) using commercial colorimetric kits and some oxidative stress biomarkers including malondialdehyde (MDA) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) by ELISA assays. We next analysed potential correlations between GLY and oxidative stress biomarkers concentration and sperm parameters (sperm concentration, progressive speed, anormal forms). Here, we detected for the first time GLY in the human seminal plasma in significant proportions and we showed that its concentration was four times higher than those observed in blood plasma. At the opposite, AMPA was undetectable. We also observed a strong positive correlation between plasma blood GLY concentrations and plasma seminal GLY and 8-OHdG concentrations, the latter reflecting DNA impact. In addition, TOS, Oxidative Stress Index (OSI) (TOS/TAS), MDA blood and seminal plasma concentrations were significantly higher in men with glyphosate in blood and seminal plasma, respectively. Taken together, our results suggest a negative impact of GLY on the human reproductive health and possibly on his progeny. A precaution principle should be applied at the time of the actual discussion of GLY and GBHs formulants uses in Europe by the authorities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S014765132400486XTest; https://doaj.org/toc/0147-6513Test |
| DOI: | 10.1016/j.ecoenv.2024.116410 |
| الوصول الحر: | https://doaj.org/article/e97e0997ee314554a5cba6f841518596Test |
| رقم الانضمام: | edsdoj.97e0997ee314554a5cba6f841518596 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.116410 |