دورية أكاديمية
Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma
| العنوان: | Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma |
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| المؤلفون: | Albrechtsen, N., Hornburg, D., Albrechtsen, R., Svendsen, B., Torang, S., Jepsen, S., Kuhre, R., Hansen, M., Janus, C., Floyd, A., Lund, A., Vilsboll, T., Knop, F., Vestergaard, H., Deacon, C., Meissner, F., Mann, M., Holst, J., Hartmann, B. |
| المصدر: | EBioMedicine |
| سنة النشر: | 2016 |
| المجموعة: | Max Planck Society: MPG.PuRe |
| الوصف: | Low-abundance regulatory peptides, including metabolically important gut hormones, have shown promising therapeutic potential. Here, we present a streamlined mass spectrometry-based platform for identifying and characterizing low-abundance regulatory peptides in humans. We demonstrate the clinical applicability of this platform by studying a hitherto neglected glucose-and appetite-regulating gut hormone, namely, oxyntomodulin. Our results show that the secretion of oxyntomodulin in patients with type 2 diabetes is significantly impaired, and that its level is increased by more than 10-fold after gastric bypass surgery. Furthermore, we report that oxyntomodulin is co-distributed and co-secreted with the insulin-stimulating and appetite-regulating gut hormone glucagon-like peptide-1 (GLP-1), is inactivated by the same protease (dipeptidyl peptidase-4) as GLP-1 and acts through its receptor. Thus, oxyntomodulin may participate with GLP-1 in the regulation of glucose metabolism and appetite in humans. In conclusion, this mass spectrometry-based platformis a powerful resource for identifying and characterizing metabolically active low-abundance peptides. (C) 2016 The Authors. Published by Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | http://hdl.handle.net/11858/00-001M-0000-002B-0094-4Test; http://hdl.handle.net/11858/00-001M-0000-002B-0096-FTest |
| الإتاحة: | https://doi.org/10.1016/j.ebiom.2016.03.034Test http://hdl.handle.net/11858/00-001M-0000-002B-0094-4Test http://hdl.handle.net/11858/00-001M-0000-002B-0096-FTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.619171D3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |