دورية أكاديمية
Anti-Tat immunity defines CD4+ T-cell dynamics in people living with HIV on long-term cART.
| العنوان: | Anti-Tat immunity defines CD4+ T-cell dynamics in people living with HIV on long-term cART. |
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| المؤلفون: | Antonella Tripiciano, Orietta Picconi, Sonia Moretti, Cecilia Sgadari, Aurelio Cafaro, Vittorio Francavilla, Angela Arancio, Giovanni Paniccia, Massimo Campagna, Maria Rosaria Pavone-Cossut, Laura Sighinolfi, Alessandra Latini, Vito S. Mercurio, Massimo Di Pietro, Francesco Castelli, Annalisa Saracino, Cristina Mussini, Giovanni Di Perri, Massimo Galli, Silvia Nozza, Fabrizio Ensoli, Paolo Monini, Barbara Ensoli |
| المصدر: | EBioMedicine, Vol 66, Iss , Pp 103306- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | HIV immune activation, HIV reservoirs, HIV residual viremia, CD4+ T cells, HIV-1 Tat, Anti-Tat antibodies, Medicine, Medicine (General), R5-920 |
| الوصف: | Background: Low-level HIV viremia originating from virus reactivation in HIV reservoirs is often present in cART treated individuals and represents a persisting source of immune stimulation associated with sub-optimal recovery of CD4+ T cells. The HIV-1 Tat protein is released in the extracellular milieu and activates immune cells and latent HIV, leading to virus production and release. However, the relation of anti-Tat immunity with residual viremia, persistent immune activation and CD4+ T-cell dynamics has not yet been defined. Methods: Volunteers enrolled in a 3-year longitudinal observational study were stratified by residual viremia, Tat serostatus and frequency of anti-Tat cellular immune responses. The impact of anti-Tat immunity on low-level viremia, persistent immune activation and CD4+ T-cell recovery was investigated by test for partitions, longitudinal regression analysis for repeated measures and generalized estimating equations. Findings: Anti-Tat immunity is significantly associated with higher nadir CD4+ T-cell numbers, control of low-level viremia and long-lasting CD4+ T-cell recovery, but not with decreased immune activation. In adjusted analysis, the extent of CD4+ T-cell restoration reflects the interplay among Tat immunity, residual viremia and immunological determinants including CD8+ T cells and B cells. Anti-Env immunity was not related to CD4+ T-cell recovery. Interpretation: Therapeutic approaches aiming at reinforcing anti-Tat immunity should be investigated to improve immune reconstitution in people living with HIV on long-term cART. Trial registration: ISS OBS T-002 ClinicalTrials.gov identifier: NCT01024556 Funding: Italian Ministry of Health, special project on the Development of a vaccine against HIV based on the Tat protein and Ricerca Corrente 2019/2020. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-3964 64210952 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2352396421000992Test; https://doaj.org/toc/2352-3964Test |
| DOI: | 10.1016/j.ebiom.2021.103306 |
| الوصول الحر: | https://doaj.org/article/347c39a646b64210952c288b56fdfe12Test |
| رقم الانضمام: | edsdoj.347c39a646b64210952c288b56fdfe12 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23523964 64210952 |
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| DOI: | 10.1016/j.ebiom.2021.103306 |