دورية أكاديمية
Early Detection of Breast Cancer by Molecular Analysis of Ductal Lavage Fluid
| العنوان: | Early Detection of Breast Cancer by Molecular Analysis of Ductal Lavage Fluid |
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| المؤلفون: | Sukumar, Saraswati |
| المساهمون: | JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE |
| المصدر: | DTIC AND NTIS |
| سنة النشر: | 2002 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Anatomy and Physiology, Medicine and Medical Research, BREAST CANCER, DETECTION, DIAGNOSIS(MEDICINE), GENES, BODY FLUIDS, MAMMARY GLANDS, DUCTAL LAVAGE FLUID |
| الوصف: | Reliable intermediate biological markers for breast cancer risk, that can be easily detected in both pre- and post- menopausal women do not exist at the present time. For more than 20 years, the ability to access breast ductal fluid through the nipple has prompted initiatives to develop a PAP-like test for breast cancer. Yields were variable, not every woman yielded fluid and there was no assurance of obtaining samples from the entire length of the ducts. In this proposal, we will use a 1) a facile ductal lavage (DL) technique using cannulating catheters which flushes each duct to yield thousands of ductal cells. 2) a panel of markers consisting of three genes, Cyclin D2, Twist and retinoic acid receptor beta 2 (RAR beta 2), which are aberrantly hypermethylated in breast cancer cells. We will standardize the techniques using fluid from cancer patients, and then evaluate the frequency of cells positive by MSP assays in ductal lavage obtained from women with a high risk of developing breast Cancer, such as patients with lobular carcinoma, patients with cancer in one breast, and those with mammographically suspicious lesions. Thus, we aim to develop a PAP test for the breast. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://www.dtic.mil/docs/citations/ADA410198Test |
| الإتاحة: | http://www.dtic.mil/docs/citations/ADA410198Test http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA410198Test |
| حقوق: | APPROVED FOR PUBLIC RELEASE |
| رقم الانضمام: | edsbas.908781B9 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |