دورية أكاديمية
North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury: A Consortium of Military, Veterans Administration and Civilian Hospitals
| العنوان: | North American Clinical Trials Network (NACTN) for Treatment of Spinal Cord Injury: A Consortium of Military, Veterans Administration and Civilian Hospitals |
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| المؤلفون: | Grossman, Robert G, Anderson, Aileen |
| المساهمون: | CHRISTOPHER REEVE FOUNDATION SHORT HILLS NJ |
| المصدر: | DTIC |
| سنة النشر: | 2009 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Medicine and Medical Research, CELLS(BIOLOGY), CLINICAL MEDICINE, CLINICAL TRIALS, MEDICAL RESEARCH, SPINAL CORD, DAMAGE, HEALING, HISTOLOGY, HOSPITALS, MODELS, PARAMETERS, RECOVERY, SENSES(PHYSIOLOGY), SPINAL COLUMN, SYNERGISM, TEST AND EVALUATION, TRANSPLANTATION, WOUNDS AND INJURIES, NACTN(NORTH AMERICAN CLINICAL TRIALS NETWORKS), SPINAL CORD INJURIES |
| الوصف: | Amnion Derived Multipotent Progenitor Cells (AMPCs) and their secreted amnion-derived cellular cytokine suspension (ACCS) may have the potential to enhance wound healing and tissue repair. The objective of this proposal is to test the ability of AMPCs and ACCS to effect recovery after spinal cord injury (SCI), according to two hypothesis-driven goals: A) Does acute (2 day delay) AMP cell transplantation after SCI improve functional locomotor recovery and histological injury measures?; and B: Is ACCS sufficient to promote recovery of function after SCI, or synergistic when administered in combination with AMP cells? AMPCs and ACCS will be transplanted into a well-established model of contusion induced SCI, contusion injury being the most common and clinically relevant form of damage in the human clinical population, according to the experimental parameters of the hypotheses outlined under the objectives and in the detailed experimental design. Regaining partial function can lead to improved functional mobility and sensation, improving quality of life and reducing lifetime costs associated with SCI. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://www.dtic.mil/docs/citations/ADA586996Test |
| الإتاحة: | http://www.dtic.mil/docs/citations/ADA586996Test http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA586996Test |
| حقوق: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.9A0B130E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |