التفاصيل البيبلوغرافية
| العنوان: |
Assessing the feasibility of using an adverse drug reaction preventability scale in clinical practice: a study in a French emergency department. |
| المؤلفون: |
Olivier, P., Boulbés, O., Tubery, M., Lauque, D., Montastruc, J-L., Lapeyre-Mestre, M., Olivier, Pascale, Boulbés, Olivier, Tubery, Marie, Lauque, Dominique, Montastruc, Jean-Louis, Lapeyre-Mestre, Maryse |
| المصدر: |
Drug Safety; Nov2002, Vol. 25 Issue 14, p1035-1044, 10p |
| مصطلحات موضوعية: |
PREVENTION of drug side effects, PHARMACOLOGY |
| مستخلص: |
Objective: To assess the preventability of adverse drug reactions (ADRs) leading to hospital admissions and to investigate the feasibility of the use of a standardised preventability scale in clinical practice.Design: The study was a prospective pharmacovigilance study. All patients more than 15 years old admitted to an emergency department during a period of 4 weeks were included. Characteristics of patients admitted for a suspected ADR (cases) were compared to those admitted for other reasons (controls). Preventability was assessed in two different ways: (i). by using a standardised preventability scale; and (ii). by the assessment of four reviewers without the scale. Results of the two methods were compared.Patients: In total, 671 patients were admitted to an emergency department during the study period.Results: Overall, 44 ADRs were identified involving 41 patients. The incidence of hospital admissions for ADRs was 6.1 per 100 admissions (95% CI 4.4-8.3). According to the French causality assessment method, 71% of ADRs were 'possible', 18% were 'plausible' and 11% were 'likely'. Using the standardised preventability scale, one-third of all ADRs were considered as being preventable (9% 'definitely' and 25% 'potentially' preventable). Reviewers found that 54.5% of ADRs were 'preventable'. Discrepancies between the two methods concerned mainly cases defined as not preventable by the scale. In general, reviewers overestimated the preventability of ADR compared with the scale.Conclusions: These results emphasise that ADRs leading to hospitalisation are frequent, with one-third of them likely to be preventable. Moreover, the risk of ADRs mainly involved a small number of drugs. Our experience suggests that there is a need for further studies to validate the French standardised scale of preventability assessment. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
