أعرض في EDS

Influence of uridine diphosphate glucuronosyltransferase inducers and inhibitors on the plasma lamotrigine concentration in pediatric patients with refractory epilepsy

التفاصيل البيبلوغرافية
العنوان: Influence of uridine diphosphate glucuronosyltransferase inducers and inhibitors on the plasma lamotrigine concentration in pediatric patients with refractory epilepsy
المؤلفون: Masahiko Nakai, Yoshiyuki Kagawa, Hiroko Ikeda, Yushi Inoue, Masaaki Takahashi, Katsumi Imai, Yoshiaki Yamamoto, Yukitoshi Takahashi
المصدر: Drug metabolism and pharmacokinetics. 30(3)
سنة النشر: 2014
مصطلحات موضوعية: Topiramate, Phenytoin, Male, Adolescent, Pharmaceutical Science, Rufinamide, Lamotrigine, Pharmacology, medicine, Humans, Pharmacology (medical), Drug Interactions, Glucuronosyltransferase, Child, Retrospective Studies, Epilepsy, medicine.diagnostic_test, Dose-Response Relationship, Drug, Chemistry, Triazines, Age Factors, Infant, Carbamazepine, Ethosuximide, Therapeutic drug monitoring, Child, Preschool, Enzyme Induction, Phenobarbital, Anticonvulsants, Drug Therapy, Combination, Female, medicine.drug
الوصف: This study evaluated the influence of concomitant antiepileptic drugs (AEDs) on the plasma concentration of lamotrigine (LTG) in pediatric patients with epilepsy. We retrospectively reviewed 1653 plasma samples from 709 patients (aged 6 months to 16 years) and compared the concentration-to-dose ratio (CD ratio) of LTG among different AED regimens. The median CD ratio of patients receiving LTG monotherapy was 1.25 μg/mL/mg/kg. In patients receiving LTG plus VPA, the CD ratio was increased by about 140%. The CD ratio was elevated from a low VPA concentration (
تدمد: 1880-0920
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fc77283c979c8d28918dbc80ddcf51Test
https://pubmed.ncbi.nlm.nih.gov/25825021Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....36fc77283c979c8d28918dbc80ddcf51
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18800920