نتائج البحث

1

Investigation of Endogenous Compounds Applicable to Drug–Drug Interaction Studies Involving the Renal Organic Anion Transporters, OAT1 and OAT3, in Humans

المؤلفون: Kazuya Maeda, Yuri Tsuruya, Koji Kato, Yuji Kumagai, Hiroyuki Kusuhara, Yuichi Sugiyama, Yuichiro Imamura, Yamato Sano

المصدر: Drug Metabolism and Disposition. 44:1925-1933

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a3a2f05906c65dd43c76e44c28cecTest
https://doi.org/10.1124/dmd.116.071472Test

2

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

المؤلفون: Punit Marathe, Dieter M. Drexler, Robert Langish, Sandhya Mandlekar, Weiqi Chen, Hong Shen, Yurong Lai, W. Griffith Humphreys, Kurex Sidik, Vinay K. Holenarsipur, Jinping Gan, Eric Shields

المصدر: Drug Metabolism and Disposition. 45:908-919

مصطلحات موضوعية: Adult, Male, Coproporphyrins, medicine.medical_specialty, Adolescent, Organic anion transporter 1, Cmax, Organic Anion Transporters, Pharmaceutical Science, Endogeny, Palmitic Acids, 030226 pharmacology & pharmacy, Cell Line, Bile Acids and Salts, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Pharmacokinetics, Internal medicine, medicine, Humans, Drug Interactions, Rosuvastatin Calcium, Pharmacology, chemistry.chemical_classification, biology, Dehydroepiandrosterone Sulfate, Fatty acid, Biological Transport, Middle Aged, Healthy Volunteers, Organic anion-transporting polypeptide, HEK293 Cells, Endocrinology, chemistry, Area Under Curve, 030220 oncology & carcinogenesis, biology.protein, Rifampin, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b372f3917f3dcf2f1541b24caa44b4c7Test
https://doi.org/10.1124/dmd.117.075531Test

3

Metabolism of the MEK1/2 Inhibitor Pimasertib Involves a Novel Conjugation with Phosphoethanolamine in Patients with Solid Tumors

المؤلفون: Friedrich Kraetzer, Holger Scheible, Andreas Marx, Andreas Johne, Elmar Wimmer

المصدر: Drug Metabolism and Disposition. 45:174-182

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ded892c5f63e4cfe0663d2bb88dd54cTest
https://doi.org/10.1124/dmd.116.072934Test

4

In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1

المؤلفون: Mary Pat Knadler, William F. Annes, Amanda J. Long, Kathleen M. Hillgren, Jennifer Witcher, Y. Anne Pak, Malcolm I. Mitchell, Phillip Leese, Mosun Ayan-Oshodi

المصدر: Drug Metabolism and Disposition

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bef06dfcf5308fc5c28924fa43784a9Test
https://doi.org/10.1124/dmd.116.071118Test

5

Utility of Oatp1a/1b-Knockout and OATP1B1/3-Humanized Mice in the Study of OATP-Mediated Pharmacokinetics and Tissue Distribution: Case Studies with Pravastatin, Atorvastatin, Simvastatin, and Carboxydichlorofluorescein

المؤلفون: J. William Higgins, Philip C. Smith, John K. Fallon, Jason Manro, Jing Q. Bao, Alice B. Ke, Maciej J. Zamek-Gliszczynski

المصدر: Drug Metabolism and Disposition. 42:182-192

مصطلحات موضوعية: Adult, Simvastatin, medicine.medical_specialty, Adolescent, Organic Cation Transport Proteins, Organic anion transporter 1, Atorvastatin, Biological Availability, Organic Anion Transporters, Pharmaceutical Science, Organic Anion Transporters, Sodium-Independent, Pharmacology, Mice, Solute Carrier Organic Anion Transporter Family Member 1B3, Young Adult, Pharmacokinetics, Internal medicine, medicine, Animals, Humans, Distribution (pharmacology), Pyrroles, Tissue Distribution, Aged, Pravastatin, Mice, Knockout, Volume of distribution, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Middle Aged, Organic anion-transporting polypeptide, Endocrinology, Liver, Heptanoic Acids, Knockout mouse, biology.protein, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c981f551ffd4c1897884592bb618d8dTest
https://doi.org/10.1124/dmd.113.054783Test

6

Identification of Human Metabolites of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites

المؤلفون: K.-I. Umehara, Nobuaki Shirai, Hidetaka Kamimura, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui

المصدر: Drug Metabolism and Disposition. 37:1646-1657

مصطلحات موضوعية: Adult, Male, Organic Cation Transport Proteins, Organic anion transporter 1, Stereochemistry, Metabolite, Administration, Oral, Pharmaceutical Science, Organic Anion Transporters, Sodium-Independent, Kidney, Transfection, Cell Line, Excretion, Feces, Young Adult, chemistry.chemical_compound, Organic Anion Transport Protein 1, Species Specificity, Tandem Mass Spectrometry, Membrane Transport Modulators, medicine, Humans, Metabolomics, Carbon Radioisotopes, Biotransformation, Chromatography, High Pressure Liquid, Pharmacology, Chromatography, Organic cation transport proteins, biology, Tetrahydroisoquinoline, Organic Cation Transporter 1, Organic Cation Transporter 2, Kidney metabolism, Biological Transport, Cardiovascular Agents, Middle Aged, Isoquinolines, medicine.anatomical_structure, Liver, chemistry, Renal physiology, Benzamides, biology.protein, Catecholamine Plasma Membrane Transport Proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946fb150b03b68451199281388ba1fbTest
https://doi.org/10.1124/dmd.108.026294Test

7

6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects

المؤلفون: Yuri Tsuruya, Noriko Okudaira, Hiroyuki Kusuhara, Yuji Kumagai, Dominik Heer, Atsushi Kurihara, Nobuyuki Murayama, Yuichiro Imamura, Kazuya Maeda, Katja Damme, Yuichi Sugiyama, Takashi Izumi

المصدر: Drug Metabolism and Disposition. 42:685-694

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeea5292a162acecf988ba396fbd7e57Test
https://doi.org/10.1124/dmd.113.055475Test

8

Indiplon Is Hydrolyzed by Arylacetamide Deacetylase in Human Liver

المؤلفون: Tatsuki Fukami, Mai Shimizu, Miki Nakajima, Tsuyoshi Yokoi, Yusuke Ito, Takaya Kurokawa, Motoki Kariya

المصدر: Drug Metabolism and Disposition. 42:751-758

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9676f84ac87bc7164b5ffc9e85bd5ee8Test
https://doi.org/10.1124/dmd.113.056184Test

9

Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir

المؤلفون: Evan D. Kharasch, Kristi Stubbert

المصدر: Drug Metabolism and Disposition. 41:2166-2174

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2176a388872dd279ac07dff89ecc7344Test
https://doi.org/10.1124/dmd.113.053991Test

10

Aldehyde Oxidase 1 (AOX1) in Human Liver Cytosols: Quantitative Characterization of AOX1 Expression Level and Activity Relationship

المؤلفون: Li Di, R. Scott Obach, Cexiong Fu, Catherine Soderstrom, Hui Zhang, Xiaogang Han, Mark Snyder, Matthew D. Troutman

المصدر: Drug Metabolism and Disposition. 41:1797-1804

مصطلحات موضوعية: Adult, Male, Pharmaceutical Science, Fractionation, Peptide Mapping, Cofactor, Young Adult, Cytosol, Tandem Mass Spectrometry, Humans, Aged, Pharmacology, chemistry.chemical_classification, biology, Chemistry, Metabolism, Middle Aged, Enzyme assay, Aldehyde Oxidase, Enzyme, Liver, Biochemistry, Toxicity, biology.protein, Female, Aldehyde oxidase 1, Chromatography, Liquid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c924a33bcf0c49cff4d7228a4f045b0eTest
https://doi.org/10.1124/dmd.113.053082Test

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