يعرض 1 - 4 نتائج من 4 نتيجة بحث عن '"(1"', وقت الاستعلام: 0.90s تنقيح النتائج
  1. 1
    Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

    المؤلفون: Punit Marathe, Dieter M. Drexler, Robert Langish, Sandhya Mandlekar, Weiqi Chen, Hong Shen, Yurong Lai, W. Griffith Humphreys, Kurex Sidik, Vinay K. Holenarsipur, Jinping Gan, Eric Shields

    المصدر: Drug Metabolism and Disposition. 45:908-919

    مصطلحات موضوعية: Adult, Male, Coproporphyrins, medicine.medical_specialty, Adolescent, Organic anion transporter 1, Cmax, Organic Anion Transporters, Pharmaceutical Science, Endogeny, Palmitic Acids, 030226 pharmacology & pharmacy, Cell Line, Bile Acids and Salts, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dehydroepiandrosterone sulfate, Pharmacokinetics, Internal medicine, medicine, Humans, Drug Interactions, Rosuvastatin Calcium, Pharmacology, chemistry.chemical_classification, biology, Dehydroepiandrosterone Sulfate, Fatty acid, Biological Transport, Middle Aged, Healthy Volunteers, Organic anion-transporting polypeptide, HEK293 Cells, Endocrinology, chemistry, Area Under Curve, 030220 oncology & carcinogenesis, biology.protein, Rifampin, Biomarkers

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b372f3917f3dcf2f1541b24caa44b4c7Test
    https://doi.org/10.1124/dmd.117.075531Test


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  2. 2
    In Vitro and Clinical Evaluations of the Drug-Drug Interaction Potential of a Metabotropic Glutamate 2/3 Receptor Agonist Prodrug with Intestinal Peptide Transporter 1

    المؤلفون: Mary Pat Knadler, William F. Annes, Amanda J. Long, Kathleen M. Hillgren, Jennifer Witcher, Y. Anne Pak, Malcolm I. Mitchell, Phillip Leese, Mosun Ayan-Oshodi

    المصدر: Drug Metabolism and Disposition

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Agonist, Adolescent, medicine.drug_class, Acyclovir, Pharmaceutical Science, Pharmacology, Receptors, Metabotropic Glutamate, Peptide Transporter 1, 030226 pharmacology & pharmacy, Substrate Specificity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, In vivo, medicine, Humans, Drug Interactions, Prodrugs, Amino Acids, IC50, Aged, Chemistry, Biological Transport, Valine, Transporter, Articles, Middle Aged, Prodrug, Drug interaction, Bridged Bicyclo Compounds, Heterocyclic, Cyclic S-Oxides, Bioavailability, 030104 developmental biology, Biochemistry, Valacyclovir, Female, HeLa Cells

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bef06dfcf5308fc5c28924fa43784a9Test
    https://doi.org/10.1124/dmd.116.071118Test


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  3. 3
    Identification of Human Metabolites of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites

    المؤلفون: K.-I. Umehara, Nobuaki Shirai, Hidetaka Kamimura, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui

    المصدر: Drug Metabolism and Disposition. 37:1646-1657

    مصطلحات موضوعية: Adult, Male, Organic Cation Transport Proteins, Organic anion transporter 1, Stereochemistry, Metabolite, Administration, Oral, Pharmaceutical Science, Organic Anion Transporters, Sodium-Independent, Kidney, Transfection, Cell Line, Excretion, Feces, Young Adult, chemistry.chemical_compound, Organic Anion Transport Protein 1, Species Specificity, Tandem Mass Spectrometry, Membrane Transport Modulators, medicine, Humans, Metabolomics, Carbon Radioisotopes, Biotransformation, Chromatography, High Pressure Liquid, Pharmacology, Chromatography, Organic cation transport proteins, biology, Tetrahydroisoquinoline, Organic Cation Transporter 1, Organic Cation Transporter 2, Kidney metabolism, Biological Transport, Cardiovascular Agents, Middle Aged, Isoquinolines, medicine.anatomical_structure, Liver, chemistry, Renal physiology, Benzamides, biology.protein, Catecholamine Plasma Membrane Transport Proteins

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6946fb150b03b68451199281388ba1fbTest
    https://doi.org/10.1124/dmd.108.026294Test


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  4. 4
    The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672

    المؤلفون: Dominic Surry, Caroline Butters, Gemma Imisson, Veronica Smith, Michael Gillen, Pradeep Sharma, Robert Elsby

    المصدر: Drug Metabolism and Disposition. 39:275-282

    مصطلحات موضوعية: Adult, Male, Quinidine, Digoxin, Adolescent, Benzeneacetamides, Administration, Oral, Pharmaceutical Science, Pharmacology, Models, Biological, Substrate Specificity, Young Adult, Therapeutic index, Pharmacokinetics, In vivo, medicine, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Sulfonamides, Molecular Structure, biology, Chemistry, Biological Transport, Middle Aged, Drug interaction, Drug Design, biology.protein, Female, Ketoconazole, Caco-2 Cells, medicine.drug

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33cc67e42c568afb19db33686ded931Test
    https://doi.org/10.1124/dmd.110.035881Test


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