Pharmacokinetic profile of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in mice after oral administration ofPolygonum multiflorumextract
| العنوان: | Pharmacokinetic profile of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside in mice after oral administration ofPolygonum multiflorumextract |
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| المؤلفون: | Letian Shan, Su-Hong Chen, Hui Gu, Zhaohuan Lou, Gui-Yuan Lv |
| المصدر: | Drug Development and Industrial Pharmacy. 38:248-255 |
| بيانات النشر: | Informa UK Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Polygonum, Administration, Oral, Pharmaceutical Science, Context (language use), Plant Roots, Mice, Glucosides, Pharmacokinetics, Oral administration, Chinese traditional, Stilbenes, Drug Discovery, Animals, Medicine, Chinese Traditional, Chromatography, High Pressure Liquid, Pharmacology, chemistry.chemical_classification, Chromatography, Reverse-Phase, Plants, Medicinal, Chromatography, biology, Chemistry, Organic Chemistry, Glycoside, biology.organism_classification, Models, Animal, Extraction methods, Plant Preparations, 2 3 5 4 tetrahydroxystilbene 2 o β d glucoside, Drugs, Chinese Herbal |
| الوصف: | Stilbene glycoside (2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside) is a main bioactive component of Polygonum multiflorum, a traditional Chinese medicine (TCM) commonly used in clinic for anti-aging treatment. Its medicinal activities, such as anti-oxidation, anti-inflammation and endothelial protection, have been extensively studied, but its pharmacokinetic property is still unclear.A pharmacokinetic study was undertaken to quantitatively determine P. multiflorum stilbene glycoside (PM-SG) in mouse plasma after oral administration of 100 mg/kg P. multiflorum extract.A sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) coupled with liquid-liquid phase extraction method was employed for this study. Pharmacokinetic parameters of PM-SG were determined in mice applying both compartmental and non-compartmental analyses.The calibration curve for PM-SG in the plasma was linear (r(2)0.99) over the range of 0.66 to 56.40 μg/ml, and the concentration-time curve was plotted with the maximum concentration (C(max)) and time to reach maximum concentration (T(max)) of 29.62 μg/ml and 60 min, respectively. The intra- and inter-day variations were less than 3% for relative standard deviation (RSD) and relative error (RE), with a good recovery of more than 97% (RSD3%). All pharmacokinetic parameters estimated by compartmental and non-compartmental models reached a same conclusion that PM-SG was rapidly absorbed and widely distributed throughout the body with a great efficiency of utility, followed by quick elimination and clearance.This was the first report on determination of the pharmacokinetic profile of PM-SG in mice after oral administration. The result may provide a meaningful basis for evaluating the clinical applications of such a bioactive compound from herbal medicines. |
| تدمد: | 1520-5762 0363-9045 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed483877676727d3dc192140602358dfTest https://doi.org/10.3109/03639045.2011.597763Test |
| رقم الانضمام: | edsair.doi.dedup.....ed483877676727d3dc192140602358df |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205762 03639045 |
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