دورية أكاديمية
Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study
| العنوان: | Development and evaluation of luteolin loaded pegylated bilosome: optimization, in vitro characterization, and cytotoxicity study |
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| المؤلفون: | Ameeduzzafar Zafar, Nabil K. Alruwaili, Syed Sarim Imam, Omar Awad Alsaidan, Mohd Yasir, Mohammed M. Ghoneim, Sultan Alshehri, Md. Khalid Anwer, Alanood S. Almurshedi, Abdullah S. Alanazi |
| المصدر: | Drug Delivery, Vol 28, Iss 1, Pp 2562-2573 (2021) |
| بيانات النشر: | Taylor & Francis Group, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | bilosomes, breast cancer, box–behnken’s design, luteolin, pegylated, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The present research was aimed to develop luteolin (LL) loaded pegylated bilosomes (PG-BLs) for oral delivery. The luteolin bilosomes (BLs) were prepared by the thin-film hydration method and further optimized by the Box–Behnken design (four-factors at three-levels). The prepared LL-BLs were evaluated for vesicle size (VS), PDI, zeta potential (ZP), and entrapment efficiency to select the optimized formulation. The optimized formulation was further assessed for surface morphology, drug release, gut permeation, antioxidant, and antimicrobial study. The cytotoxicity study was conducted on breast cancer cell lines (MDA-MB-231 and MCF7). The optimized formulation LL-PG-BLs-opt exhibited a VS of 252.24 ± 3.54 nm, PDI of 0.24, ZP of −32 mV with an encapsulation efficiency of 75.05 ± 0.65%. TEM study revealed spherical shape vesicles without aggregation. The DSC and XRD results revealed that LL was encapsulated into a PG-BLs matrix. LL-PG-BLs-opt exhibited a biphasic release pattern as well as significantly high permeation (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1071-7544 1521-0464 10717544 |
| العلاقة: | https://doaj.org/toc/1071-7544Test; https://doaj.org/toc/1521-0464Test |
| DOI: | 10.1080/10717544.2021.2008055 |
| الوصول الحر: | https://doaj.org/article/8da2e3bfcd574daa861aa28d14fc7502Test |
| رقم الانضمام: | edsdoj.8da2e3bfcd574daa861aa28d14fc7502 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2021.2008055 |