Long Noncoding RNA miR210HG Sponges miR-503 to Facilitate Osteosarcoma Cell Invasion and Metastasis
| العنوان: | Long Noncoding RNA miR210HG Sponges miR-503 to Facilitate Osteosarcoma Cell Invasion and Metastasis |
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| المؤلفون: | Quan-Min Wu, Jiang Li, Xiao-Qing Wang, Cheng-Qiang Zhang |
| المصدر: | DNA and Cell Biology. 36:1117-1125 |
| بيانات النشر: | Mary Ann Liebert Inc, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Epithelial-Mesenchymal Transition, Mice, Nude, Bone Neoplasms, Vimentin, Bioinformatics, medicine.disease_cause, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, microRNA, Genetics, medicine, Animals, Humans, Gene silencing, Neoplasm Invasiveness, Neoplasm Metastasis, 3' Untranslated Regions, Molecular Biology, Cell Proliferation, Mice, Inbred BALB C, Osteosarcoma, Gene knockdown, biology, Cell Biology, General Medicine, Prognosis, medicine.disease, Long non-coding RNA, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, biology.protein, RNA, Long Noncoding, Carcinogenesis |
| الوصف: | Long noncoding RNAs (lncRNAs) have been illustrated to function as important regulator in carcinogenesis and cancer progression. However, roles of lncRNA miR210HG (miR210 host gene) in osteosarcoma remain unclear. In this study, miR210HG expression level was significantly upregulated in 55 cases of osteosarcoma tissue samples compared to adjacent normal tissue. Besides, the aberrantly enhanced miR210HG expression predicted poor prognosis and lower survival rate. In vitro, miR210HG knockdown suppressed the osteosarcoma cell proliferation, invasion, and epithelial-mesenchymal transition-related marker (N-cadherin and vimentin) expression. In vivo, miR210HG silencing decreased the tumor growth. miR-503 was verified to be the target miRNA of miR210HG using bioinformatics online program and luciferase assay. Furthermore, miR-503 could reverse the role of miR210HG on osteosarcoma cells. In conclusion, our study indicates that miR210HG sponges miR-503 to facilitate osteosarcoma cell invasion and metastasis, revealing the oncogenic role of miR210HG on osteosarcoma cells. |
| تدمد: | 1557-7430 1044-5498 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f187185d89cf008db1256a8048b00aTest https://doi.org/10.1089/dna.2017.3888Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d1f187185d89cf008db1256a8048b00a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15577430 10445498 |
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