دورية أكاديمية
Use of Host- and Bacteria-Derived Salivary Markers in Detection of Periodontitis: A Cumulative Approach
| العنوان: | Use of Host- and Bacteria-Derived Salivary Markers in Detection of Periodontitis: A Cumulative Approach |
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| المؤلفون: | Ulvi Kahraman Gursoy, Eija Könönen, Pirkko J. Pussinen, Taina Tervahartiala, Kati Hyvärinen, Anna L. Suominen, Veli-Jukka Uitto, Susanna Paju, Timo Sorsa |
| المصدر: | Disease Markers, Vol 30, Iss 6, Pp 299-305 (2011) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2011 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | In the present study, we propose a novel diagnostic approach, using 3 different salivary markers, representing periodontal pathogen burden, inflammation, and tissue degradation, for detecting periodontitis. The salivary concentrations of Porphyromonas gingivalis, interleukin-1β, and matrix metalloproteinase-8, available from salivary specimens of 165 subjects (84 subjects with advanced periodontitis and 81 controls), were calculated together to obtain a cumulative risk score (CRS). In the calculation of CRS, the concentrations of each marker were divided into tertiles, and cumulative sub-score per each subject were calculated by the multiplication of the tertile values. Three CRS groups, indicating the lowest, medium, or highest risk, were formed with the cumulative sub-scores. Logistic regression analysis and ROC curves were performed to study the association of CRS with periodontitis. The results indicate that CRS, calculated from the 3 salivary biomarkers, is associated with advanced periodontitis more strongly than any of the markers individually. CRS offers a novel, non-invasive model for advanced periodontitis risk categorization that is especially useful in large population surveys where a periodontal examination is not feasible. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0278-0240 1875-8630 |
| العلاقة: | http://dx.doi.org/10.3233/DMA-2011-0788Test; https://doaj.org/toc/0278-0240Test; https://doaj.org/toc/1875-8630Test; https://doaj.org/article/3fc67f8d45a44a5c84e93a75e5409b47Test |
| DOI: | 10.3233/DMA-2011-0788 |
| الإتاحة: | https://doi.org/10.3233/DMA-2011-0788Test https://doaj.org/article/3fc67f8d45a44a5c84e93a75e5409b47Test |
| رقم الانضمام: | edsbas.B54F3FE1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 02780240 18758630 |
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| DOI: | 10.3233/DMA-2011-0788 |