The Value of CA 125 and CA72-4 in Management of Patients with Epithelial Ovarian Cancer
| العنوان: | The Value of CA 125 and CA72-4 in Management of Patients with Epithelial Ovarian Cancer |
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| المؤلفون: | Samar K. Kassim, Salah T. Fayed, Samira M. Ahmad, Ali Khalifa |
| المصدر: | Disease Markers, Vol 14, Iss 3, Pp 155-160 (1998) Disease Markers |
| بيانات النشر: | Hindawi Limited, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adult, suboptimal cytoreduction, medicine.medical_specialty, Pathology, endocrine system diseases, optimal cytoreduction, medicine.medical_treatment, Clinical Biochemistry, Ovary, Disease, Sensitivity and Specificity, Gastroenterology, CA125, Antigen, Internal medicine, Genetics, medicine, Humans, Antigens, Tumor-Associated, Carbohydrate, Neoplasms, Glandular and Epithelial, Molecular Biology, Aged, Tumor marker, Ovarian Neoplasms, Chemotherapy, lcsh:R5-920, medicine.diagnostic_test, business.industry, Biochemistry (medical), General Medicine, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, CA72-4, ovarian cancer, medicine.anatomical_structure, tumor markers, CA-125 Antigen, Immunoassay, Female, Other, Ovarian cancer, business, lcsh:Medicine (General), Adjuvant, Follow-Up Studies |
| الوصف: | The role of the tumor markers CA125 and CA72-4 has been evaluated in the diagnosis and management of ovarian cancer. Both markers were measured in 30 patients with proven epithelial ovarian cancer, 30 patients with benign pelvic masses and 30 normal women. CA125 and CA72-4 were measured using the luminometric immunoassay and immuno-radiometric assay respectively. All patients with ovarian cancer were submitted to surgical staging and cytoreduction followed by adjuvant platinum based chemotherapy for 3–6 courses. Fixing the specificity at 95%, CA125 had a sensitivity of 76.7% at a cut-off 85u/ml while CA72-4 had a sensitivity of 70% at a cut-off 8.5 u/ml. The combination of CA72-4 with CA125 increased the sensitivity to 95% while fixing the specificity at 95%. Among seven cases with stage I and II ovarian cancer five cases had CA125 level below 85 U/ml, three patients out of them had CA72-4 above 8.5 U/ml. CA 72-4 could reflect the residual disease following cytoreduction and could improve the detection of relapse by CA125.Conclusion: CA72-4 could complement the standard tumor marker CA125 both in diagnosis and follow up of patients with epithelial ovarian cancer. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1875-8630 0278-0240 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e5c497237a6b98fb3a057d64a8d428Test https://doaj.org/article/8bccd52fd3ea45afb64856e4540573cdTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c5e5c497237a6b98fb3a057d64a8d428 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758630 02780240 |
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