Real-Life Multimarker Monitoring in Patients with Heart Failure: Continuous Remote Monitoring of Mobility and Patient-Reported Outcomes as Digital End Points in Future Heart-Failure Trials
| العنوان: | Real-Life Multimarker Monitoring in Patients with Heart Failure: Continuous Remote Monitoring of Mobility and Patient-Reported Outcomes as Digital End Points in Future Heart-Failure Trials |
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| المؤلفون: | Salko Smajlovic, Stephan Rosenkranz, Michele Senni, Chad Gwaltney, Stephan Cichos, Kinjal Patel, Jason Sims, Toeresin Karakoyun, Paolo Piraino, Sanjiv J. Shah, Praneeth Chennuru, Chrysanthi Dori, Wilfried Dinh, Ayse Paydar, Luke Bamber, Hans-Dirk Düngen, Alexandra Müller, Gabriele Jenny Köhler, Richard L. Clark, Savina Nodari, Thomas Viethen, Javed Butler, Christian Jung, Frank Kramer, Rob van Lummel |
| المساهمون: | Kramer, F, Butler, J, Shah, S, Jung, C, Nodari, S, Rosenkranz, S, Senni, M, Bamber, L, Cichos, S, Dori, C, Karakoyun, T, Köhler, G, Patel, K, Piraino, P, Viethen, T, Chennuru, P, Paydar, A, Sims, J, Clark, R, van Lummel, R, Müller, A, Gwaltney, C, Smajlovic, S, Düngen, H, Dinh, W |
| المصدر: | Digital Biomarkers, Vol 4, Iss 2, Pp 45-59 (2020) Digit Biomark |
| بيانات النشر: | Karger Publishers, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cardiac function curve, heart failure with preserved ejection fraction, medicine.medical_specialty, patient monitoring, activity monitors, Medicine (miscellaneous), heart failure, Health Informatics, patient-reported outcome, Further Section, Article, remote sensing, Quality of life, male, six minute walk test, medicine, echocardiography, In patient, controlled study, heart failure with reduced ejection fraction, human, outcome assessment, lcsh:QH301-705.5, Ejection fraction, electronic patient record, business.industry, adult, questionnaire, medicine.disease, major clinical study, Kansas City Cardiomyopathy Questionnaire, Computer Science Applications, female, multicenter study, wearables, priority journal, lcsh:Biology (General), Blood biomarkers, patient-reported outcomes, Heart failure, Emergency medicine, Biomarker (medicine), biomarker, Observational study, observational study, business, cardiomyopathy, prospective study |
| الوصف: | Aims: Heart failure (HF) affects approximately 26 million people worldwide. With an aging global population, innovative approaches to HF evaluation and management are needed to cope with the worsening HF epidemic. The aim of the Real-Life Multimarker Monitoring in Patients with Heart Failure (REALIsM-HF) study (NCT03507439) is to evaluate a composite instrument comprising remote, real-time, activity-monitoring devices combined with daily electronic patient-reported outcome (ePRO) items in patients who have been hospitalized for HF and are undergoing standard HF assessment (e.g., 6-min walking distance [6MWD], blood biomarkers, Kansas City Cardiomyopathy Questionnaire [KCCQ], and echocardiography). Methods: REALIsM-HF is an ongoing, 12-week, observational study enrolling 80–100 patients aged ≥45 years with HF with preserved ejection fraction (HFpEF; EF ≥45%) or reduced EF (HFrEF; EF ≤35%). Statistical analyses will include examining the association between data from wearables (the AVIVO© mobile patient management patch or VitalPatch© biosensor, and the DynaPort MoveMonitor©), daily ePROs, and conventional HF metrics (e.g., serum/plasma biomarkers, 6MWD, KCCQ, and echocardiographic parameters). The feasibility of and patient compliance with at-home devices will be documented, and the data captured for the purpose of establishing reference values in patients with HFpEF or HFrEF will be summarized. Conclusions: The REALIsM-HF study is to evaluate the longitudinal daily activity profiles of patients with HF and correlate these with changes in serum/plasma biomarker profiles, symptoms, quality of life, and cardiac function and morphology to inform the use of wearable activity monitors for developing novel therapies and managing patients. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7650afdb8d239ca1ddd438db6d2f711eTest https://www.karger.com/Article/FullText/507696Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7650afdb8d239ca1ddd438db6d2f711e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |