High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California
| العنوان: | High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California |
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| المؤلفون: | Takeshi Chida, Enkhjargal Tsogtoo, Carolina Lim, Bo-Ram Bang, Esugen D. Dashdorj, Namuun E. Clifford, Tse-Ling Fong, Takeshi Saito, Brian T. Lee, Ping Liu, Khishigsuren Nasanbayar, Masashi Mizokami, Jeffrey S. Glenn, Naranjargal Dashdorj, Masaya Sugiyama, Mimi Chang, Arghun N. Dashdorj, Naranbaatar Dashdorj, Delgerbat Boldbaatar |
| المصدر: | Digestive Diseases and Sciences. |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, HBsAg, Cirrhosis, Physiology, business.industry, viruses, Incidence (epidemiology), Gastroenterology, virus diseases, Hepatitis C, Hepatology, Hepatitis B, medicine.disease, digestive system diseases, 03 medical and health sciences, 0302 clinical medicine, HBeAg, 030220 oncology & carcinogenesis, Internal medicine, Medicine, 030211 gastroenterology & hepatology, business, Viral hepatitis |
| الوصف: | Mongolia is a highly endemic region for chronic hepatitis B (HBV), hepatitis delta (HDV), and hepatitis C (HCV) infections. Aim of this study was to comprehensively characterize chronic viral hepatitis among Mongols living in Southern California. Three screening events were conducted between August and November 2018, with 528 adult Mongols tested for HBV and HCV. HBsAg (+) individuals (CHB) underwent additional testing for HDV RNA and anti-HDV. Liver tests, platelet count, and FibroScan™ were performed on CHB and chronic HCV (CHC) individuals. Fifty-one out of 534 were HBsAg reactive (9.7%), and all were foreign-born. Mean age of CHB individuals was 37.8 (range 18–69) years. Forty-six out of 51 were HBeAg (–). HBV genotypes were exclusively D2 or A1. Twenty-one out of 51 (41.2%) were anti-HDV (+) and 17/51 (33.3%) were HDV RNA (+). HDV RNA (+) individuals had significantly higher ALT, fibrosis-4 score, and liver stiffness compared to HDV RNA (–) individuals. Incidence of advanced fibrosis was higher in HDV RNA (+) individuals (57% vs. 13%, p = 0.013). Forty-eight (9.1%) individuals were anti-HCV (+) and 19 (3.6%) were HCV RNA (+). Mean age of CHC individuals was 40.2 (range 28–71) years. Prevalence of anti-HCV (+) was higher among those born between 1945 and 1965 versus those born after 1965 (18.8% vs. 7.9%, p = 0.025). Genotype 1b was predominant. Incidence of cirrhosis was 7% among all participants. Mongols living in the USA are at high risk for CHB and CHC infections. One-third of CHB individuals had CHD superinfection with advanced fibrosis. Universal screening for viral hepatitis in Mongols in the USA is mandatory. |
| تدمد: | 1573-2568 0163-2116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e14693b5394d6a93cc9a475ad4614eacTest https://doi.org/10.1007/s10620-020-06499-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........e14693b5394d6a93cc9a475ad4614eac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732568 01632116 |
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