Delays in Initiating Post-operative Prophylactic Biologic Therapy Are Common Among Crohn’s Disease Patients
| العنوان: | Delays in Initiating Post-operative Prophylactic Biologic Therapy Are Common Among Crohn’s Disease Patients |
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| المؤلفون: | Madison Dennis, Adam F. Steinlauf, Ellen Scherl, Shirley Cohen-Mekelburg, Fabrizio Michelassi, Yecheskel Schneider, Stephanie Gold, Heather L. Yeo, Clara Oromendia |
| المصدر: | Digestive Diseases and Sciences. 64:196-203 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Physiology, medicine.medical_treatment, Inflammatory bowel disease, Cohort Studies, 0302 clinical medicine, Crohn Disease, Risk Factors, Intestine, Small, Secondary Prevention, Certolizumab pegol, Cecum, Colectomy, Digestive System Surgical Procedures, Crohn's disease, Gastroenterology, Bowel resection, Middle Aged, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, medicine.drug, Cohort study, Adult, medicine.medical_specialty, Antibodies, Monoclonal, Humanized, Medicare, Time-to-Treatment, 03 medical and health sciences, Ileum, Internal medicine, Preoperative Care, Adalimumab, medicine, Humans, Retrospective Studies, Postoperative Care, Biological Products, Insurance, Health, Medicaid, business.industry, Retrospective cohort study, medicine.disease, Infliximab, United States, Logistic Models, Multivariate Analysis, Certolizumab Pegol, business |
| الوصف: | Studies have shown that prophylactic biologic therapy can reduce post-surgical Crohn’s disease recurrence. We aimed to identify the frequency of delay and risk factors associated with a delay in the initiation of prophylactic post-surgical biologic therapy in high-risk patients. We performed a cohort study of Crohn’s disease patients who underwent a bowel resection. We identified those at risk of recurrence and explored multiple characteristics for those with and without a delay post-operatively. A total of 84 patients were included in our analysis of which 69.0% had a greater than 4-week delay and 56.0% a greater than 8-week delay in post-surgical biologic prophylaxis. Publicly insured patients had a 100% delay in post-surgical prophylaxis initiation (p = 0.039, p = 0.003 at 4 and 8 weeks, respectively). Patients on a biologic pre-surgery were less likely to have a delay (p |
| تدمد: | 1573-2568 0163-2116 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9510b3130efa438dda426af03fe2f7eTest https://doi.org/10.1007/s10620-018-5159-4Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d9510b3130efa438dda426af03fe2f7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732568 01632116 |
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