Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis
| العنوان: | Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis |
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| المؤلفون: | Antonino Carlo Privitera, Antonio Rispo, C. Ferracane, Maria Cappello, Raffaele Melina, Francesco William Guglielmi, Angelo Andriulli, Rocco Spagnuolo, Fabrizio Bossa, Giuseppe Costantino, M. Mendolaro, Mariabeatrice Principi, Agnese Miranda, Pietro Paese, Alessandro Azzarone, Ladislava Sebkova, Silvia Mazzuoli, Olga Maria Nardone, R. Clemente, Antonio Tursi, Marco Romano, M. Patturelli, A. Lauria, Endrit Shahini, C. Ricciardelli, Caterina Sgarro, L. Fanigliulo, Laurino Grossi, Gabriele Riegler, Walter Fries, Giuseppe Pranzo, Nello Buccianti, Gaetano Inserra, Giuseppe Biscaglia, Maria Rosa Valvano |
| المساهمون: | Bossa, F, Biscaglia, G, Valvano, Mr, Costantino, G, Lauria, A, Clemente, R, Ferracane, C, Shahini, E, Mendolaro, M, Grossi, L, Mazzuoli, S, Rispo, A, Pranzo, G, Sebkova, L, Tursi, A, Miranda, A, Patturelli, M, Spagnuolo, R, Ricciardelli, C, Sgarro, C, Paese, P, Inserra, G, Azzarone, A, Nardone, O, Fries, W, Buccianti, N, Privitera, Ac, Principi, Mb, Cappello, M, Guglielmi, Fw, Romano, M, Riegler, G, Fanigliulo, L, Melina, R, Andriulli, A. |
| المصدر: | Digestive diseases and sciences. 65(6) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Multivariate analysis, Physiology, Biologics, Inflammatory bowel disease, Golimumab, Cohort Studies, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Autoinjector, Internal medicine, Medicine, Humans, Adverse effect, Dose-Response Relationship, Drug, business.industry, Gastroenterology, Anti-TNF-alpha, Ulcerative colitis, Antibodies, Monoclonal, Hepatology, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Colitis, Ulcerative, Female, Calprotectin, business, medicine.drug |
| الوصف: | Golimumab is a new anti-TNF-alpha monoclonal antibody for patients with ulcerative colitis. To assess the short- and long-term effectiveness and safety of golimumab in daily clinical practice and to identify predictors of response. Consecutive patients treated with golimumab in 22 Italian centers were enrolled. Clinical, laboratory, and endoscopic data were prospectively collected before and during treatment. A subgroup of patients completed a questionnaire to assess personal satisfaction with a golimumab autoinjector system. A total of 196 patients were included. After 3 months, 130 patients were responders (66.3%) and showed significant reductions in mean partial, total, and endoscopic Mayo scores and in mean ESR, C-reactive protein, and fecal calprotectin levels (p |
| تدمد: | 1573-2568 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e55e1b6e0c2abaf9b5ee1bc38def14Test https://pubmed.ncbi.nlm.nih.gov/31722059Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....e9e55e1b6e0c2abaf9b5ee1bc38def14 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15732568 |
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