التفاصيل البيبلوغرافية
| العنوان: |
Serum HCV RNA levels correlate with histological liver damage and concur with steatosis in progression of chronic hepatitis C. |
| المؤلفون: |
Adinolfi, Luigi, Utili, Riccardo, Andreana, Augusto, Tripodi, Marie-Francoise, Marracino, Marta, Gambardella, Michele, Giordano, Mariagrazia, Ruggiero, Giuseppe, Adinolfi, L E, Utili, R, Andreana, A, Tripodi, M F, Marracino, M, Gambardella, M, Giordano, M, Ruggiero, G |
| المصدر: |
Digestive Diseases & Sciences; Aug2001, Vol. 46 Issue 8, p1677-1683, 7p |
| مستخلص: |
The role of HCV RNA levels and host factors in the severity of liver injury was studied. Enrolled were 298 consecutive liver biopsy-proven chronic hepatitis (CH) C patients (179 men; median age: 52 years, range 19-68; CH, 198; cirrhosis, 100) and 18 chronic hepatitis C with normal ALT. HCV genotypes were: 1a, 4.3%; 1b, 53%; 2a/c, 28%; 3a, 7%; 4, 1.3%, and mixed 6.4%. Serum HCV RNA levels were similar for all genotypes (median: 2.8 x 10(6) eq/ml; range <0.2-69). In patients with chronic hepatitis without cirrhosis, the serum HCV RNA levels reflected the grade of liver necroinflammatory activity (R = 0.45; P < 0.001) and the stage of fibrosis (R = 0.51; P < 0.001), regardless of age, gender, HCV genotype, hepatic steatosis, and hepatic iron overload. Patients with high serum HCV RNA levels (> or =3 x 10(6) eq/ml) had higher ALT values (P < 0.002) than those with lower HCV RNA levels. Patients with normal ALT showed low HCV RNA levels (median: 0.82 x 10(6) eq/ml) and histological features of minimal or mild chronic hepatitis. Cirrhotic patients showed significantly lower levels of viremia than those with chronic hepatitis with a similar HAI. The data of a subgroup of 62 patients with an established time of infection showed that for a similar duration of disease, patients with serum HCV RNA levels > or =3 x 10(6) eq/ml had a significantly higher fibrosis score than those with lower levels. HAI and fibrosis score were significantly higher in patients with HCV RNA levels > or =3 x 10(6) eq/ml and grade 3-4 steatosis than those with lower HCV RNA levels and steatosis grades. The data indicate that the liver damage is correlated with the HCV RNA levels and that a high viral load acts together with steatosis in accelerating the progression of liver injury. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
