التفاصيل البيبلوغرافية
| العنوان: |
Glycyrrhizin Enhances Therapeutic Activity of a Colon-Specific Methylprednisolone Prodrug Against Experimental Colitis. |
| المؤلفون: |
Lee, Yonghyun1, Jeong, Seongkeun1, Kim, Wooseong1, Kim, Hyunjeong1, Yoon, Jeong-Hyun1, Jeong, Seong2, Jung, Yunjin1 jungy@pusan.ac.kr |
| المصدر: |
Digestive Diseases & Sciences. May2013, Vol. 58 Issue 5, p1226-1234. 9p. |
| مصطلحات موضوعية: |
*TRITERPENES, *METHYLPREDNISOLONE, *COLITIS treatment, *DRUG administration, *GLUCOCORTICOIDS, *DRUG therapy, *INFLAMMATORY bowel disease treatment, *PRODRUGS |
| مستخلص: |
Background: Co-administration of a reduction inhibitor and a colon-specific prodrug of a glucocorticoid susceptible to colonic reductive metabolism is suggested as a strategy to circumvent the therapeutic loss of the glucocorticoid delivered to and acting locally at the large intestine. Aims: We examined whether the strategy was feasible as a pharmacotherapy for treatment of inflammatory bowel disease. Methods: Glycyrrhizin (GCZ), a reduction inhibitor, was tested for its inhibition of the colonic metabolism of methylprednisolone (MP). Therapeutic activity against TNBS-induced rat colitis and adrenal suppression were compared after oral administration of methylprednisolone 21-sulfate sodium (MPS), a colon-specific prodrug of MP, or MPS/GCZ to colitic rats. Results: Upon incubation of MP with the cecal contents, MP disappeared, and this was delayed by addition of GCZ. In addition, more MP produced from MPS in the cecal contents accumulated in the presence of GCZ. Consistent with these results, upon oral administration of MPS/GCZ, MPS or MP, MP was detected at a greater level in the large intestine for MPS/GCZ. MPS/GCZ ameliorated TNBS-induced colitis of rats, and this therapeutic effect was superior to that of MPS and MP. Moreover, MPS/GCZ decreased the plasma levels of corticosterone and ACTH to a greater extent than MPS, but less than MP. Conclusions: Co-administration of GCZ, a reduction inhibitor, may be a plausible strategy to reduce the therapeutic loss of MP produced from MPS in the large intestine, thus improving the therapeutic property of the prodrug against inflammatory bowel disease. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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