Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease
| العنوان: | Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease |
|---|---|
| المؤلفون: | Eugen Trinka, Stefan Golaszewski, Martin Kronbichler, Kerstin Schwenker, Frank Rattay, Raffaele Nardone, Vanessa N. Frey, Larissa Hauer, Bettina Wutzl, Johann Sellner, Axel F Unterrainer, Cristina Florea |
| المصدر: | Diagnostics Diagnostics, Vol 10, Iss 309, p 309 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cerebellum, Clinical Biochemistry, Central nervous system, Posterior parietal cortex, Case Report, coma, Disease, 03 medical and health sciences, 0302 clinical medicine, Degenerative disease, 030202 anesthesiology, medicine, sensorimotor cortex, Coma, lcsh:R5-920, medicine.diagnostic_test, business.industry, Unconsciousness, vibration paradigm, medicine.disease, apallic syndrome, functional magnetic resonance imaging, Creutzfeldt-Jakob disease, medicine.anatomical_structure, alinetic mutism, medicine.symptom, Functional magnetic resonance imaging, business, lcsh:Medicine (General), Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations. |
| اللغة: | English |
| تدمد: | 2075-4418 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5832262132bc52390fbf352a994506eeTest http://europepmc.org/articles/PMC7277986Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5832262132bc52390fbf352a994506ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20754418 |
|---|